2. Academic Validation
  3. CD36 regulates LPS-induced acute lung injury by promoting macrophages M1 polarization

CD36 regulates LPS-induced acute lung injury by promoting macrophages M1 polarization

  • Cell Immunol. 2022 Feb:372:104475. doi: 10.1016/j.cellimm.2021.104475.
Shishuo Sun 1,  Yizhou Yao 2,  Chao Huang 1,  Heng Xu 1,  Yuxiao Zhao 3,  Yifei Wang 3,  Yizhang Zhu 3,  Yangna Miao 4,  Xinhui Feng 1,  Xiaoge Gao 1,  Junnian Zheng 5,  Qing Zhang 6
Affiliations

Affiliations

  • 1 Cancer Institute, the First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, PR China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, PR China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, PR China.
  • 2 Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, PR China.
  • 3 Cancer Institute, the First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, PR China.
  • 4 Cancer Institute, the First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, PR China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, PR China.
  • 5 Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, PR China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, PR China. Electronic address: [email protected].
  • 6 Cancer Institute, the First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, PR China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, PR China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, PR China. Electronic address: [email protected].
PMID: 35063904 DOI: 10.1016/j.cellimm.2021.104475
Abstract

M1 polarization of macrophages works as a promoter in pathogenesis of acute lung injury / acute respiratory distress syndrome (ALI/ARDS) by the secretion of pro-inflammatory cytokines and recruiting Other inflammatory cells. Lipopolysaccharide (LPS), a critical component of the wall of gram-negative bacteria, can induce M1 polarization and ALI. Recently, cluster of differentiation 36 (CD36) has been reported to be associated with inflammatory responses. However, it has not yet been clarified whether CD36 in macrophages is involved in LPS-induced ALI. Herein, we demonstrated that in macrophages, LPS-induced ALI was regulated by CD36. Loss of CD36 attenuated LPS-induced ALI by reducing M1 polarization. Mechanistically, CD36 promoted macrophage M1 polarization by regulating CD14 associated with TLR4 during LPS stimulation. The findings of this study, clarified the mechanism of LPS-induced ALI through CD36 in macrophages, which provides a potential target for the prevention and treatment of ALI.

Keywords

Acute lung injury; CD36; Macrophage polarization; NF-κB.

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