2. Academic Validation
  3. Rhein Prevents APAP-induced drug-induced Liver Injury by Upregulating Nrf2 and Inhibiting APAP-activating Enzymes

Rhein Prevents APAP-induced drug-induced Liver Injury by Upregulating Nrf2 and Inhibiting APAP-activating Enzymes

  • Cell Biochem Biophys. 2026 Jan 18. doi: 10.1007/s12013-026-02005-3.
Mingda Liu 1,  Jin Dai 2,  Liangding Dou 1,  Zifeng Deng 1 3,  Junxian Liu 1,  Xin Hou 1,  Jinwen Zhang 1 4,  YongChao Huang 1,  Zhi Huang 1,  Dai Wang 1,  Dongbei Guo 1,  Ran An 1,  Youliang Yao 1,  Yongxing Zhang 5
Affiliations

Affiliations

  • 1 State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, xiamen City, Fujian province, China.
  • 2 Jinshan College, Fujian Agriculture and Forestry University, Fujian Province, Fuzhou City, 350000, China.
  • 3 School of Public Health, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, 999077, PR China.
  • 4 Zherong County Center for Disease, Control and Prevention, Ningde City, Fujian Province, 352000, China.
  • 5 State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, xiamen City, Fujian province, China. [email protected].
PMID: 41548181 DOI: 10.1007/s12013-026-02005-3
Keywords

APAP; APAP-activating enzymes; Drug-induced liver injury; Nrf2; RA.

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