2. GPCR/G Protein
  3. Apelin Receptor (APJ)
  4. ML233

ML233 is a non-peptide based potent apelin receptor (APJ) agonist (EC50=3.7 μM). ML233 displays >21-fold selective over the closely related angiotensin 1 (AT1) receptor (>79 μM).

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ML233

ML233 Chemical Structure

CAS No. : 2080311-92-6

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ML233 Related Antibodies

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Description

ML233 is a non-peptide based potent apelin receptor (APJ) agonist (EC50=3.7 μM). ML233 displays >21-fold selective over the closely related angiotensin 1 (AT1) receptor (>79 μM)[1].

IC50 & Target

EC50: 3.7 μM (Apelin receptor)[1]
In Vitro

ML233 shows potentially significant binding against several other receptors, including the 5-HT1A, α2C adrenergic, and benzylpiperazine receptors and norepinephrine transporter. ML233 shows some toxicity (LC50=25.8 μM) toward human hepatocyctes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ML233 Related Antibodies
Masse moléculaire

359.44

Formule

C19H21NO4S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(C1CCCCC1)=C/2)C=C(C)C2=N/OS(=O)(C3=CC=CC=C3)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

DMSO : 15 mg/mL (41.73 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7821 mL 13.9105 mL 27.8211 mL
5 mM 0.5564 mL 2.7821 mL 5.5642 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Pureté et documentation

Purity: 99.8%

SDS (251 KB)

COA (249 KB) Elemental Analysis Report (107 KB)

Instruction de manipulation (2659 KB)
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7821 mL 13.9105 mL 27.8211 mL 69.5526 mL
5 mM 0.5564 mL 2.7821 mL 5.5642 mL 13.9105 mL
10 mM 0.2782 mL 1.3911 mL 2.7821 mL 6.9553 mL
15 mM 0.1855 mL 0.9274 mL 1.8547 mL 4.6368 mL
20 mM 0.1391 mL 0.6955 mL 1.3911 mL 3.4776 mL
25 mM 0.1113 mL 0.5564 mL 1.1128 mL 2.7821 mL
30 mM 0.0927 mL 0.4637 mL 0.9274 mL 2.3184 mL
40 mM 0.0696 mL 0.3478 mL 0.6955 mL 1.7388 mL
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ML233 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML2332080311-92-6ML 233ML-233Apelin Receptor (APJ)GPCRprobepermeabletoxicitycardiovascularhomeostasisheartfailureInhibitorinhibitorinhibit

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Nom du produit:
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Cat. No.:
HY-125976
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