2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS)
  4. N-Acetyl-L-cysteine ethyl ester

N-Acetyl-L-cysteine ethyl ester  (Synonyms: N-Acetylcysteine ethyl ester; NACET)

製品番号: HY-134495 純度: 99.87%
COA 取扱説明書 Technical Support

N-Acetyl-L-cysteine ethyl ester is an esterified form of N-acetyl-L-cysteine (NAC). N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H2S) and can be used as an H2S producer. N-Acetyl-L-cysteine ethyl ester has the potential to substitute NAC as a mucolytic agent, and as a GSH-related antioxidant.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 59587-09-6

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 35 在庫あり
Solution
10 mM * 1 mL in DMSO USD 35 在庫あり
Solid
5 mg $32 在庫あり
10 mg $50 在庫あり
25 mg $88 在庫あり
50 mg $140 在庫あり
100 mg $250 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 11 publication(s) in Google Scholar

N-Acetyl-L-cysteine ethyl ester 関連抗体

Top Publications Citing Use of Products

    N-Acetyl-L-cysteine ethyl ester purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Apr:139:156512.  [Abstract]

    Inhibition of ROS generation can reverse CCL5-induced lung cancer cell proliferation. H1299 and H226 cells were treated with CCL5 protein and then with NAC (N-Acetyl-L-cysteine ​​ethyl ester). Cell proliferation was detected by EdU staining.

    N-Acetyl-L-cysteine ethyl ester purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Apr:139:156512.  [Abstract]

    Inhibition of ROS generation can reverse CCL5-induced lung cancer cell proliferation. H12996 cells were treated with CCL5 protein and then with NAC (N-Acetyl-L-cysteine ​​ethyl ester). Western blot analysis was used to detect the protein levels of Cyclin D1, PCNA, Nrf2, and Keap1.

    N-Acetyl-L-cysteine ethyl ester purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2024 Sep 16:107420.  [Abstract]

    Cell viability was determined in response to ROS scavenger NAC (N-Acetyl-L-cysteine ethyl ester).

    N-Acetyl-L-cysteine ethyl ester purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Nov 10;43(11):114915.  [Abstract]

    ROS level in the colon of SD-5d, SD-5d+NAC (N-Acetyl-L-cysteine ethyl ester: 150 mg/kg), and control mice.

    N-Acetyl-L-cysteine ethyl ester purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Nov 10;43(11):114915.  [Abstract]

    Weight changes in SD-5d, SD-5d+NAC (N-Acetyl-L-cysteine ethyl ester: 150 mg/kg) and control mice.

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    N-Acetyl-L-cysteine ethyl ester is an esterified form of N-acetyl-L-cysteine (NAC). N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H2S) and can be used as an H2S producer. N-Acetyl-L-cysteine ethyl ester has the potential to substitute NAC as a mucolytic agent, and as a GSH-related antioxidant[1].

    体外実験

    N-Acetyl-L-cysteine ethyl ester is a an esterified form of N-acetyl-L-cysteine (NAC). N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H2S) and can be used as an H2S producer. N-Acetyl-L-cysteine ethyl ester has the potential to substitute NAC as a mucolytic agent, and as a GSH-related antioxidant[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    N-Acetyl-L-cysteine ethyl ester 関連抗体
    分子量

    191.25

    分子式

    C7H13NO3S
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    SC[C@@H](C(OCC)=O)NC(C)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (522.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : ≥ 100 mg/mL (522.88 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.2288 mL 26.1438 mL 52.2876 mL
    5 mM 1.0458 mL 5.2288 mL 10.4575 mL
    10 mM 0.5229 mL 2.6144 mL 5.2288 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (13.07 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (13.07 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.87%

    COA (247 KB) HNMR (230 KB) RP-HPLC (244 KB) MS (69 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 5.2288 mL 26.1438 mL 52.2876 mL 130.7190 mL
    5 mM 1.0458 mL 5.2288 mL 10.4575 mL 26.1438 mL
    10 mM 0.5229 mL 2.6144 mL 5.2288 mL 13.0719 mL
    15 mM 0.3486 mL 1.7429 mL 3.4858 mL 8.7146 mL
    20 mM 0.2614 mL 1.3072 mL 2.6144 mL 6.5359 mL
    25 mM 0.2092 mL 1.0458 mL 2.0915 mL 5.2288 mL
    30 mM 0.1743 mL 0.8715 mL 1.7429 mL 4.3573 mL
    40 mM 0.1307 mL 0.6536 mL 1.3072 mL 3.2680 mL
    50 mM 0.1046 mL 0.5229 mL 1.0458 mL 2.6144 mL
    60 mM 0.0871 mL 0.4357 mL 0.8715 mL 2.1786 mL
    80 mM 0.0654 mL 0.3268 mL 0.6536 mL 1.6340 mL
    100 mM 0.0523 mL 0.2614 mL 0.5229 mL 1.3072 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    N-Acetyl-L-cysteine ethyl ester Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    N-Acetyl-L-cysteine ethyl ester59587-09-6N-Acetylcysteine ethyl ester NACETReactive Oxygen Species (ROS)oxidative stress-relateddiseaseantioxidantH2Scysteinemucolytic agentInhibitorinhibitorinhibit

    最近チェックした製品:

    オンラインお問い合わせ

    Your information is safe with us. * Required Fields.

    製品名

    		  

    カスタマ需要量 *

    お名前 *

    		 

    タイトル

    メールアドレス *

    		 

    電話番号 *

    デパートメント

    		 

    組纖名 *

    市区町村

    都道府県

    国或いは地域 *

    		      

    必ず会社名を記載ください。個人への返信は行いません。

    備考

    バルクお問い合わせ

    Inquiry Information

    製品名:
    N-Acetyl-L-cysteine ethyl ester
    製品番号:
    HY-134495
    数量:
    MCE 日本正規代理店:

    カスタマーレビュー

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    製品名

    		  

    Lot #

    お名前 *

    		 

    メールアドレス *

    電話番号 *

    		 

    部門 *

    組纖名 *

    		 

    国或いは地域 *

    備考

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.