1. Metabolic Enzyme/Protease
  2. MAGL
  3. N-Arachidonyl maleimide

N-Arachidonyl maleimide 

Cat. No.: HY-136562
Handling Instructions

N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC50 value of 140 nM.

For research use only. We do not sell to patients.

N-Arachidonyl maleimide Chemical Structure

N-Arachidonyl maleimide Chemical Structure

CAS No. : 876305-42-9

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N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC50 value of 140 nM[1].

IC50 & Target

IC50: 140 nM (MAGL)[1]

In Vitro

N-Arachidonyl maleimide is a putative MAGL inhibitor, which can be used for modulation of the effects of 2-arachidonyl glycerol (2-AG). N-Arachidonyl maleimide increases endogenous levels of 2-AG in the brain. N-Arachidonyl maleimide prevents cerebellar membrane-mediated degradation of 2-AG at a relatively low concentration (IC50, 140 nM)[1].

In Vivo

When combined with a 1 mg/kg dose of N-Arachidonyl maleimide, 2-AG (1, 3, and 10 mg/kg) produces significant and dose-dependent hypothermia, inhibition of locomotor activity, antinociception, and catalepsy[1].

Molecular Weight









Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

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N-Arachidonyl maleimideMAGLMonoacylglycerol lipasemonoacylglycerollipase2-AGInhibitorinhibitorinhibit

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