O-Desmethyltramadol

Cat. No.: HY-109054: Fiche technique Instruction de manipulation
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O-Desmethyltramadol is the main active metabolite of tramadol (Tramadol) and can cross the blood-brain barrier. O-Desmethyltramadol mainly exerts its analgesic effect by activating the µ-opioid receptor (µ-OR).

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O-Desmethyltramadol Chemical Structure

CAS No. : 80456-81-1

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50 mg		Obtenir un devis
100 mg		Obtenir un devis
250 mg		Obtenir un devis
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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of O-Desmethyltramadol:

O-Desmethyltramadol hydrochloride

Other Forms of O-Desmethyltramadol:

O-Desmethyltramadol hydrochloride In-stock
O-Desmethyl Tramadol-d₆ Obtenir un devis

Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform Opioid Receptor:

Voir toutes les isoformes

μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

Activité biologique
Pureté et documentation
Références
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	120 1 Compound: Des-methyltramadol	Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF assay Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF assay	[PMID: 24900459]
CHO	EC₅₀	120 1 Compound: Des-methyltramadol	Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF assay Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF assay	[PMID: 24900459]
CHO	EC₅₀	120 1 Compound: Des-methyltramadol	Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF assay Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF assay	[PMID: 24900459]
CHO	EC₅₀	240 1 Compound: 5; (+/-)-M1	Agonist activity at human MOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assay Agonist activity at human MOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assay	[PMID: 27096047]
CHO	EC₅₀	240 1 Compound: 5; (+/-)-M1	Agonist activity at human MOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assay Agonist activity at human MOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assay	[PMID: 27096047]
CHO	EC₅₀	240 1 Compound: 5; (+/-)-M1	Agonist activity at human MOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assay Agonist activity at human MOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assay	[PMID: 27096047]

In Vitro

O-Desmethyltramadol can be metabolized from Tramadol through the cytochrome P450 (CYP) 2D6 enzyme^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

249.35

Formule

C₁₅H₂₃NO₂

CAS No.

80456-81-1

SMILES

O[C@@](CCCC1)(C2=CC(O)=CC=C2)[C@H]1CN(C)C

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Lee J, et al. Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6. Drug Des Devel Ther. 2019;13:1751-1761. [Content Brief]

[2]. Liu HC, et al. Transportation of the enantiomers of trans tramadol and O-demethyltramadol across blood-brain barrier. Yao Xue Xue Bao. 2001 Sep;36(9):644-7. Chinese. [Content Brief]