O-Desmethyltramadol hydrochloride
Based on 1 Customer Validation
O-Desmethyltramadol hydrochloride is the main active metabolite of tramadol (Tramadol) and can cross the blood-brain barrier. O-Desmethyltramadol hydrochloride mainly exerts its analgesic effect by activating the µ-opioid receptor (µ-OR).
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 185453-02-5
- Formula: C15H24ClNO2
- Molecular Weight:285.81
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
O-Desmethyltramadol hydrochloride can be metabolized from Tramadol through the cytochrome P450 (CYP) 2D6 enzyme[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 185453-02-5
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Appearance Solid
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Molecular Weight 285.81
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Formula C15H24ClNO2
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Color White to off-white
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SMILES
OC1=CC=CC([C@]2(O)[C@@H](CN(C)C)CCCC2)=C1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : ≥ 100 mg/mL (349.88 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (564 KB)
- English - EN (564 KB)
- Français - FR (564 KB)
- Deutsch - DE (564 KB)
- Norwegian - NO (564 KB)
- Español - ES (564 KB)
- Swedish - SV (564 KB)
- Italian - IT (564 KB)
- Korean - KR (564 KB)
- Portuguese - PT (564 KB)
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Handling Instructions (2659 KB)
References
[1]. Lee J, et al. Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6. Drug Des Devel Ther. 2019;13:1751-1761. [Content Brief]
[2]. Liu HC, et al. Transportation of the enantiomers of trans tramadol and O-demethyltramadol across blood-brain barrier. Yao Xue Xue Bao. 2001 Sep;36(9):644-7. Chinese. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.4988 mL | 17.4941 mL | 34.9883 mL | 87.4707 mL |
| 5 mM | 0.6998 mL | 3.4988 mL | 6.9977 mL | 17.4941 mL | |
| 10 mM | 0.3499 mL | 1.7494 mL | 3.4988 mL | 8.7471 mL | |
| 15 mM | 0.2333 mL | 1.1663 mL | 2.3326 mL | 5.8314 mL | |
| 20 mM | 0.1749 mL | 0.8747 mL | 1.7494 mL | 4.3735 mL | |
| 25 mM | 0.1400 mL | 0.6998 mL | 1.3995 mL | 3.4988 mL | |
| 30 mM | 0.1166 mL | 0.5831 mL | 1.1663 mL | 2.9157 mL | |
| 40 mM | 0.0875 mL | 0.4374 mL | 0.8747 mL | 2.1868 mL | |
| 50 mM | 0.0700 mL | 0.3499 mL | 0.6998 mL | 1.7494 mL | |
| 60 mM | 0.0583 mL | 0.2916 mL | 0.5831 mL | 1.4578 mL | |
| 80 mM | 0.0437 mL | 0.2187 mL | 0.4374 mL | 1.0934 mL | |
| 100 mM | 0.0350 mL | 0.1749 mL | 0.3499 mL | 0.8747 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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