185453-02-5
185453-02-5
Chemical Structure
O-Desmethyltramadol hydrochloride
- CAS No.: 185453-02-5
- Formula:C15H24ClNO2
- Molecular Weight:285.81
IUPAC Name: 3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol hydrochloride
InChIKey: IRGWVAWLHXDKIX-PBCQUBLHSA-N
SMILES: OC1=CC=CC([C@]2(O)[C@@H](CN(C)C)CCCC2)=C1.Cl
Biological Activity: O-Desmethyltramadol hydrochloride is the main active metabolite of tramadol (Tramadol) and can cross the blood-brain barrier. O-Desmethyltramadol hydrochloride mainly exerts its analgesic effect by activating the µ-opioid receptor (µ-OR)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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O-Desmethyltramadol hydrochloride | 99.79% | O-Desmethyltramadol hydrochloride is the main active metabolite of tramadol (Tramadol) and can cross the blood-brain barrier. O-Desmethyltramadol hydrochloride mainly exerts its analgesic effect by activating the µ-opioid receptor (µ-OR). | ||||||||||||||||||||
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References
- [1]. Lee J, et al. Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6. Drug Des Devel Ther. 2019;13:1751-1761. [Content Brief]
- [2]. Liu HC, et al. Transportation of the enantiomers of trans tramadol and O-demethyltramadol across blood-brain barrier. Yao Xue Xue Bao. 2001 Sep;36(9):644-7. Chinese. [Content Brief]
Keywords
