2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Drug Metabolite Opioid Receptor
  4. O-Desmethyltramadol

O-Desmethyltramadol is the main active metabolite of tramadol (Tramadol) and can cross the blood-brain barrier. O-Desmethyltramadol mainly exerts its analgesic effect by activating the µ-opioid receptor (µ-OR).

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O-Desmethyltramadol

O-Desmethyltramadol Chemische Struktur

CAS. Nr. : 80456-81-1

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Other In-stock Forms of O-Desmethyltramadol:

Other Forms of O-Desmethyltramadol:

O-Desmethyltramadol Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Beschreibung

O-Desmethyltramadol is the main active metabolite of tramadol (Tramadol) and can cross the blood-brain barrier. O-Desmethyltramadol mainly exerts its analgesic effect by activating the µ-opioid receptor (µ-OR)[1][2].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
120 nM
Compound: Des-methyltramadol
Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF assay
Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF assay
[PMID: 24900459]
CHO EC50
240 nM
Compound: 5; (+/-)-M1
Agonist activity at human MOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assay
Agonist activity at human MOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assay
[PMID: 27096047]
In Vitro

O-Desmethyltramadol can be metabolized from Tramadol through the cytochrome P450 (CYP) 2D6 enzyme[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

O-Desmethyltramadol Related Antibodies
Molekulargewicht

249.35

Formel

C15H23NO2
CAS. Nr.
SMILES

O[C@@](CCCC1)(C2=CC(O)=CC=C2)[C@H]1CN(C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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O-Desmethyltramadol Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

O-Desmethyltramadol80456-81-1Drug MetaboliteOpioid ReceptorO-DemethyltramadolTramadolcytochrome P450CYP2D6analgesicmetaboliteInhibitorinhibitorinhibit

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