O-Desmethyltramadol hydrochloride

Name: O-Desmethyltramadol hydrochloride
Brand: MedChemExpress
SKU: HY-109054A
Rating: 4.5 (0 reviews)

Cat. No.: HY-109054A Purity: 99.79%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

O-Desmethyltramadol hydrochloride is the main active metabolite of tramadol (Tramadol) and can cross the blood-brain barrier. O-Desmethyltramadol hydrochloride mainly exerts its analgesic effect by activating the µ-opioid receptor (µ-OR).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

O-Desmethyltramadol hydrochloride 화학구조

CAS No. : 185453-02-5

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of O-Desmethyltramadol hydrochloride:

O-Desmethyltramadol-d₆ hydrochloride 견적 받기
O-Desmethyltramadol 견적 받기

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•Related Small Molecules:

•Related Proteins:

View All Opioid Receptor Isoform Specific Products:

View All Isoforms

μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

O-Desmethyltramadol hydrochloride can be metabolized from Tramadol through the cytochrome P450 (CYP) 2D6 enzyme^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

285.81

화학식

C₁₅H₂₄ClNO₂

CAS No.

185453-02-5

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=CC([C@]2(O)[C@@H](CN(C)C)CCCC2)=C1.Cl

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

H₂O : ≥ 100 mg/mL (349.88 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4988 mL	17.4941 mL	34.9883 mL
5 mM	0.6998 mL	3.4988 mL	6.9977 mL
10 mM	0.3499 mL	1.7494 mL	3.4988 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.79%

Select Batch:

Data Sheet (274 KB) SDS (564 KB)

COA (253 KB) HNMR (174 KB) RP-HPLC (165 KB) MS (135 KB)

Handling Instructions (2659 KB)

References

[1]. Lee J, et al. Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6. Drug Des Devel Ther. 2019;13:1751-1761. [Content Brief]

[2]. Liu HC, et al. Transportation of the enantiomers of trans tramadol and O-demethyltramadol across blood-brain barrier. Yao Xue Xue Bao. 2001 Sep;36(9):644-7. Chinese. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.4988 mL	17.4941 mL	34.9883 mL	87.4707 mL
	5 mM	0.6998 mL	3.4988 mL	6.9977 mL	17.4941 mL
	10 mM	0.3499 mL	1.7494 mL	3.4988 mL	8.7471 mL
	15 mM	0.2333 mL	1.1663 mL	2.3326 mL	5.8314 mL
	20 mM	0.1749 mL	0.8747 mL	1.7494 mL	4.3735 mL
	25 mM	0.1400 mL	0.6998 mL	1.3995 mL	3.4988 mL
	30 mM	0.1166 mL	0.5831 mL	1.1663 mL	2.9157 mL
	40 mM	0.0875 mL	0.4374 mL	0.8747 mL	2.1868 mL
	50 mM	0.0700 mL	0.3499 mL	0.6998 mL	1.7494 mL
	60 mM	0.0583 mL	0.2916 mL	0.5831 mL	1.4578 mL
	80 mM	0.0437 mL	0.2187 mL	0.4374 mL	1.0934 mL
	100 mM	0.0350 mL	0.1749 mL	0.3499 mL	0.8747 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.