2. Metabolic Enzyme/Protease Apoptosis
  3. Lactate Dehydrogenase Apoptosis
  4. Oxamic acid sodium

Sodium oxamate  (Synonyms: Oxamic acid (sodium); オキサミド酸ナトリウム)

製品番号: HY-W013032A 純度: 99.72%
COA 取扱説明書 Technical Support

Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis.

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CAS 番号 : 565-73-1

容量 価格（税別） 在庫状況 数量
100 mg $30 在庫あり
500 mg $35 在庫あり
1 g $40 在庫あり
5 g $50 在庫あり
10 g   お問い合わせ  
50 g   お問い合わせ  

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カスタマーレビュー

Based on 58 publication(s) in Google Scholar

Other Forms of Oxamic acid sodium:

Sodium oxamate 関連抗体

Top Publications Citing Use of Products

顧客検証

Cell Proliferation/Viability Assay
Bio/Physico-chemical Assay
IP
WB
RT-PCR
IF

    Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2025 Jan 21:488:137310.  [Abstract]

    After treating BV-2 cells with 0 or 10 µM oxamate (OX) for 2 h, cells were treated with 0 % or 6 % CSE for 24 h. Representative immunoblot images of NLRP3.

    Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545.  [Abstract]

    HT1376 and RT112 cells were treated with or without Oxamic acid (Oxamate) (10 mM; 24 h), then treated with continuous doses of EV for 24 h and harvested for CCK-8 assays to measure the IC50 values of EV.

    Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545.  [Abstract]

    HT1376 and RT112 cells were treated with or without Oxamic acid (Oxamate) (10 mM; 1-5 d) and then collected for the CCK-8 assay.

    Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545.  [Abstract]

    HT1376 cells were treated with or without Oxamic acid (Oxamate) (10 mM) and then collected for colony formation assay.

    Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545.  [Abstract]

    Lactate dehydrogenase inhibitor Oxamic acid (Oxamate) (10 mM; 24 h) reduced lactate production in HT1376 and RT112 cells.

    Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 9;44(4):115545.  [Abstract]

    Lactate dehydrogenase inhibitor Oxamic acid (Oxamate) (10 mM; 24 h) reduced total lactylation levels in HT1376 and RT112 cells.

    Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Jun 20:75:103246.  [Abstract]

    Oxamic acid (Ox) (20 mM; 24 h) markedly inhibits the expression of fibrogenic genes (snail1, snail2, and twist1) in AGEs-stimulated mTEC, but no significant effect on quiescent cells.

    Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Jun 20:75:103246.  [Abstract]

    Oxamic acid (Ox) (0.75 g/kg; i.p.; once daily for 4 weeks). Immunofluorescent staining of E-cadherin (red), ɑ-SMA (green), and DAPI (blue).

    Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Jun 20:75:103246.  [Abstract]

    Oxamic acid (Ox) (20 mM; 24 h) treatment in AGEs-induced mTEC dramatically downregulated the levels of Pan kla and H3K14la.

    Oxamic acid sodium purchased from MedChemExpress. Usage Cited in: Theranostics. 2023 Jul 3;13(11):3856-3871.  [Abstract]

    Oxamic acid (10 mM) reverses the increase of Klac-HMGB1 levels in H/R-Ko hepatocytes.

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    製品説明

    Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3].

    Cellular Effect
    Cell Line Type Value Description References
    A549 IC50
    45.8 mM
    Compound: Oxamate sodium
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability at incubated for 72 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability at incubated for 72 hrs by MTT assay
    		[PMID: 31129449]
    MIA PaCa-2 IC50
    18.9 mM
    Compound: Oxamate sodium
    Antiproliferative activity against human MIAPaCa2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MIAPaCa2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 31129449]
    体外実験

    Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells[1].
    Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells[2].
    Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells[2].
    Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells[2].
    Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Sodium oxamate 関連抗体

    Cell Proliferation Assay[2]

    Cell Line: CNE-1 and CNE-2 cells
    Concentration: 10 μM
    Incubation Time: 24-72 hours
    Result: Showed IC50s of 74.6, 32.4 and 17.8 mM and 62.3, 44.5, 31.6 mM at 24, 48 and 72 h in the CNE-1 and CNE-2 cancer cells, respectively.

    Apoptosis Analysis[2]

    Cell Line: NPC cells
    Concentration: 0, 20, 50 and 100 mM
    Incubation Time: 48 hours
    Result: Showed the increasement of early and late apoptotic cells in a dose-dependent manner.
    Increased the expression of pro-apoptotic Bax and cleaved-caspase-3, while reduced the anti-apoptotic signals of Bcl-2 and pro-caspase-3.

    Cell Cycle Analysis[2]

    Cell Line: CNE-1 and CNE-2 cells
    Concentration: 0, 20, 50 and 100 mM
    Incubation Time: 24 hours
    Result: Showed a dose-dependent increase in the numbers of CNE-1 and CNE-2 cells in the G2/M phase.
    体内実験

    Oxamic acid (intraperitoneal injection; 750 mg/kg; once daily; 3 w) treatment improves the efficacy of tumor inhibition in vivo when combined with irradiation treatment[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female Balb/c nude mice injected with CNE-1 cells[2]
    Dosage: 750 mg/kg
    Administration: Intraperitoneal injection; 750 mg/kg; once daily; 3 weeks
    Result: Inhibited the tumor growth when compared to either oxamate alone or irradiation alone.
    分子量

    111.03

    分子式

    C2H2NNaO3
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    [Na].O=C(O)C(=O)N
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 50 mg/mL (450.33 mM; Need ultrasonic)

    DMSO : 3.23 mg/mL (29.09 mM; ultrasonic and warming and adjust pH to 5 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 9.0066 mL 45.0329 mL 90.0658 mL
    5 mM 1.8013 mL 9.0066 mL 18.0132 mL
    10 mM 0.9007 mL 4.5033 mL 9.0066 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

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    体内:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  Saline

      Solubility: 75 mg/mL (675.49 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.72%

    COA (246 KB) LCMS (83 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 9.0066 mL 45.0329 mL 90.0657 mL 225.1644 mL
    5 mM 1.8013 mL 9.0066 mL 18.0131 mL 45.0329 mL
    10 mM 0.9007 mL 4.5033 mL 9.0066 mL 22.5164 mL
    15 mM 0.6004 mL 3.0022 mL 6.0044 mL 15.0110 mL
    20 mM 0.4503 mL 2.2516 mL 4.5033 mL 11.2582 mL
    25 mM 0.3603 mL 1.8013 mL 3.6026 mL 9.0066 mL
    H2O 30 mM 0.3002 mL 1.5011 mL 3.0022 mL 7.5055 mL
    40 mM 0.2252 mL 1.1258 mL 2.2516 mL 5.6291 mL
    50 mM 0.1801 mL 0.9007 mL 1.8013 mL 4.5033 mL
    60 mM 0.1501 mL 0.7505 mL 1.5011 mL 3.7527 mL
    80 mM 0.1126 mL 0.5629 mL 1.1258 mL 2.8146 mL
    100 mM 0.0901 mL 0.4503 mL 0.9007 mL 2.2516 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Oxamic acid sodium Related Classifications

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Oxamic acid565-73-1Sodium oxamateLactate DehydrogenaseApoptosisLDHanti-tumor activityanti-proliferative activityinduce apoptosisCNE-1CNE-2A2780SKOV3Inhibitorinhibitorinhibit

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    製品番号:
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