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  4. p-Tolualdehyde

p-Tolualdehyde is the active small molecule, that could used as drug intermediate.

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p-Tolualdehyde

p-Tolualdehyde 構造式

CAS 番号 : 104-87-0

容量 価格（税別） 在庫状況 数量
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25 g $30 在庫あり
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250 g $90 在庫あり
500 g $108 在庫あり
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Based on 2 publication(s) in Google Scholar

Other Forms of p-Tolualdehyde:

p-Tolualdehyde 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

p-Tolualdehyde is the active small molecule, that could used as drug intermediate[1].

IC50 & Target

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
B16-F10 IC50
70.74 3
Compound: 15-4
Cytotoxicity against mouse B16F10 cells assessed as reduction in cell viability
Cytotoxicity against mouse B16F10 cells assessed as reduction in cell viability
[PMID: 30594028]
B16-F10 IC50
70.74 3
Compound: 15-4
Cytotoxicity against mouse B16F10 cells assessed as reduction in cell viability
Cytotoxicity against mouse B16F10 cells assessed as reduction in cell viability
[PMID: 30594028]
体外実験

p-Tolualdehyde can be used for synthesis of isoxazole derivative, which could further used to develop multidrug resistance (MDR) reversal agents[1].
p-Tolualdehyde is the model compound, that forms a more fluorescent compound DPSH-To with fluorescent probe DPSH for aldehyde compound determination[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

p-Tolualdehyde 関連抗体
分子量

120.15

分子式

C8H8O
CAS 番号
Appearance

Liquid (Density: 1.019 g/cm3)

Color

Colorless to light yellow

SMILES

CC1=CC=C(C=O)C=C1
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶剤 & 溶解度
体外: 

DMSO : 200 mg/mL (1664.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.3229 mL 41.6146 mL 83.2293 mL
5 mM 1.6646 mL 8.3229 mL 16.6459 mL
10 mM 0.8323 mL 4.1615 mL 8.3229 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (41.61 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5 mg/mL (41.61 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.16%

COA (247 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 8.3229 mL 41.6146 mL 83.2293 mL 208.0732 mL
5 mM 1.6646 mL 8.3229 mL 16.6459 mL 41.6146 mL
10 mM 0.8323 mL 4.1615 mL 8.3229 mL 20.8073 mL
15 mM 0.5549 mL 2.7743 mL 5.5486 mL 13.8715 mL
20 mM 0.4161 mL 2.0807 mL 4.1615 mL 10.4037 mL
25 mM 0.3329 mL 1.6646 mL 3.3292 mL 8.3229 mL
30 mM 0.2774 mL 1.3872 mL 2.7743 mL 6.9358 mL
40 mM 0.2081 mL 1.0404 mL 2.0807 mL 5.2018 mL
50 mM 0.1665 mL 0.8323 mL 1.6646 mL 4.1615 mL
60 mM 0.1387 mL 0.6936 mL 1.3872 mL 3.4679 mL
80 mM 0.1040 mL 0.5202 mL 1.0404 mL 2.6009 mL
100 mM 0.0832 mL 0.4161 mL 0.8323 mL 2.0807 mL
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p-Tolualdehyde Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p-Tolualdehyde104-87-0Drug IntermediateEnvironmental PollutantsDrug IintermediateEnvironmental ContaminantsInhibitorinhibitorinhibit

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製品名:
p-Tolualdehyde
製品番号:
HY-W012860
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