2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Panitumumab

Panitumumab  (Synonyms: ABX-EGF)

製品番号: HY-P99041 純度: 99.77%
COA Technical Support

Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer.

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CAS 番号 : 339177-26-3

容量 価格（税別） 在庫状況 数量
>無料サンプル (100 μg)   今すぐ申し込む  
1 mg $220 在庫あり
5 mg $650 在庫あり
10 mg $1040 在庫あり
25 mg $1880 在庫あり
50 mg $3000 在庫あり
100 mg $4800 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of Panitumumab:

Panitumumab 関連抗体

Top Publications Citing Use of Products

    Panitumumab purchased from MedChemExpress. Usage Cited in: Sci Rep. 2022 Jul 7;12(1):11561.  [Abstract]

    HeLa cells were pretreated with 100 nM cetuximab (Cmab) or 30 nM panitumumab (Pmab) for 10 min and then stimulated with 20 ng/mL TNF-α for 15 or 60 min. The expression of the indicated proteins was detected by immunoblotting.

    Panitumumab purchased from MedChemExpress. Usage Cited in: Sci Rep. 2022 Jul 7;12(1):11561.  [Abstract]

    Panitumumab (100 nM, 25 min) was internalized upon stimulation with TNF-α (20 ng/mL, 15 min) in HeLa cells.

    EGFR アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer[1][2][4].

    Isotype

    Human IgG2 kappa
    Recommend Isotype Controls
    Species Reactivity

    Human
    IC50 & Target

    EGFR
    体外実験

    Panitumumab (2 nM-2 μM, 3 h) inhibits ligand-dependent autophosphorylation in EGFR-expressing NCI-H1975 cells, NCI-H1650 cells and CHO cells[3].
    Panitumumab (0-200 μg/mL, 48 h) inhibits the proliferation of DLD-1 cells[4].
    Panitumumab (80 μg/mL, 24 h) increase beclin-1 (a marker of autophagy) levels in Caco-2 cells and DLD-1 cells[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Panitumumab 関連抗体

    Western Blot Analysis[3]

    Cell Line: EGFR-expressing NCI-H1975 cells, NCI-H1650 cells and CHO cells
    Concentration: 2, 20, 200, 2000 nM
    Incubation Time: 3 h
    Result: Inhibited ligand-induced autophosphorylation of EGFR.
    体内実験

    Panitumumab (25-500 μg per mouse, i.p., twice a week) inhibits tumor growth in the xenograft models of NCI-H1975 and NCI-H1650 in mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: NCI-H1975 and NCI-H1650 xenografts[3]
    Dosage: 25, 100, or 500 μg/mouse
    Administration: Intraperitoneal injection (i.p.), twice a week
    Result: Inhibited ligand-induced EGFR phosphorylation, tumor growth, and markers of proliferation.
    Decreased Ki-67 and phospho- mitogen-activated protein kinase (pMAPK) staining in both xenografts.
    Gene ID

    1956  [NCBI]

    Accession

    P00533-1
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    分子量

    144.32 kDa

    CAS 番号
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Panitumumab]
    輸送条件

    Shipping with dry ice.
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    保管条件

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • Human IgG2 kappa
    Biological Activity
    • Immobilized EGFR Protein, Human can bind Panitumumab. The EC50 for this effect is 47.19 ng/mL.
    • Panitumumab has a significant ADCP effect on CHOK1-human EGFR cells in a dose-dependent manner.The EC50 for this effect is 130.4 ng/mL.
    純度とドキュメンテーション

    純度: 99.77%

    COA (232 KB) SDS-PAGE (91 KB) SEC-HPLC (149 KB)

    Inhibitory Antibodies User Guide (603 KB)
    参考文献
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Panitumumab Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Panitumumab339177-26-3ABX-EGFEGFREpidermal growth factor receptorErbB-1HER1human IgG2anti-EGFRmonoclonal antibodyanti-tumorNCI-H1975NCI-H1650CHODLD-1Caco-2Inhibitorinhibitorinhibit

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    製品名:
    Panitumumab
    製品番号:
    HY-P99041
    数量:
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