2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Panitumumab

Panitumumab  (Synonyms: ABX-EGF)

Cat. No.: HY-P99041 Pureté: 99.77%
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Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer.

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CAS No. : 339177-26-3

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Based on 2 publication(s) in Google Scholar

Other Forms of Panitumumab:

Panitumumab Related Antibodies

Top Publications Citing Use of Products

    Panitumumab purchased from MedChemExpress. Usage Cited in: Sci Rep. 2022 Jul 7;12(1):11561.  [Abstract]

    HeLa cells were pretreated with 100 nM cetuximab (Cmab) or 30 nM panitumumab (Pmab) for 10 min and then stimulated with 20 ng/mL TNF-α for 15 or 60 min. The expression of the indicated proteins was detected by immunoblotting.

    Panitumumab purchased from MedChemExpress. Usage Cited in: Sci Rep. 2022 Jul 7;12(1):11561.  [Abstract]

    Panitumumab (100 nM, 25 min) was internalized upon stimulation with TNF-α (20 ng/mL, 15 min) in HeLa cells.

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    Description

    Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer[1][2][4].

    Isotype

    Human IgG2 kappa
    Recommend Isotype Controls
    Species Reactivity

    Human
    IC50 & Target

    EGFR
    In Vitro

    Panitumumab (2 nM-2 μM, 3 h) inhibits ligand-dependent autophosphorylation in EGFR-expressing NCI-H1975 cells, NCI-H1650 cells and CHO cells[3].
    Panitumumab (0-200 μg/mL, 48 h) inhibits the proliferation of DLD-1 cells[4].
    Panitumumab (80 μg/mL, 24 h) increase beclin-1 (a marker of autophagy) levels in Caco-2 cells and DLD-1 cells[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Panitumumab Related Antibodies

    Western Blot Analysis[3]

    Cell Line: EGFR-expressing NCI-H1975 cells, NCI-H1650 cells and CHO cells
    Concentration: 2, 20, 200, 2000 nM
    Incubation Time: 3 h
    Result: Inhibited ligand-induced autophosphorylation of EGFR.
    In Vivo

    Panitumumab (25-500 μg per mouse, i.p., twice a week) inhibits tumor growth in the xenograft models of NCI-H1975 and NCI-H1650 in mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: NCI-H1975 and NCI-H1650 xenografts[3]
    Dosage: 25, 100, or 500 μg/mouse
    Administration: Intraperitoneal injection (i.p.), twice a week
    Result: Inhibited ligand-induced EGFR phosphorylation, tumor growth, and markers of proliferation.
    Decreased Ki-67 and phospho- mitogen-activated protein kinase (pMAPK) staining in both xenografts.
    Gene ID

    1956  [NCBI]

    Accession

    P00533-1
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Masse moléculaire

    144.32 kDa

    CAS No.
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Panitumumab]
    Livraison

    Shipping with dry ice.
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Stockage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • Human IgG2 kappa
    Biological Activity
    • Immobilized EGFR Protein, Human can bind Panitumumab. The EC50 for this effect is 47.19 ng/mL.
    • Panitumumab has a significant ADCP effect on CHOK1-human EGFR cells in a dose-dependent manner.The EC50 for this effect is 130.4 ng/mL.
    Pureté et documentation

    Purity: 99.77%

    SDS (251 KB)

    COA (232 KB) SDS-PAGE (91 KB) SEC-HPLC (149 KB)

    Inhibitory Antibodies User Guide (603 KB)
    Références
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    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Panitumumab Related Classifications

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Panitumumab339177-26-3ABX-EGFEGFREpidermal growth factor receptorErbB-1HER1human IgG2anti-EGFRmonoclonal antibodyanti-tumorNCI-H1975NCI-H1650CHODLD-1Caco-2Inhibitorinhibitorinhibit

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