PC Biotin-PEG3-azide

Name: PC Biotin-PEG3-azide
Brand: MedChemExpress
SKU: HY-140132
Rating: 4.5 (0 reviews)

Cat. No.: HY-140132 Purity: 97.75%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

PC Biotin-PEG3-azide is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). PC Biotin-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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PC Biotin-PEG3-azide 화학구조

CAS No. : 1937270-46-6

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

PC Biotin-PEG3-azide is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. PC Biotin-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

825.93

화학식

C₃₅H₅₅N₉O₁₂S

CAS No.

1937270-46-6

Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(OC(C1=CC(OC)=C(OCCCC(NCCOCCOCCOCCNC(CCCC[C@H]2SC[C@@]([C@@]2([H])N3)([H])NC3=O)=O)=O)C=C1[N+]([O-])=O)C)NCCCN=[N+]=[N-]

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

용액&용해도

In Vitro:

DMSO : 50 mg/mL (60.54 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2108 mL	6.0538 mL	12.1076 mL
5 mM	0.2422 mL	1.2108 mL	2.4215 mL
10 mM	0.1211 mL	0.6054 mL	1.2108 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 97.75%

Select Batch:

Data Sheet (266 KB) SDS (466 KB)

COA (242 KB) HNMR (343 KB) RP-HPLC (249 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2108 mL	6.0538 mL	12.1076 mL	30.2689 mL
	5 mM	0.2422 mL	1.2108 mL	2.4215 mL	6.0538 mL
	10 mM	0.1211 mL	0.6054 mL	1.2108 mL	3.0269 mL
	15 mM	0.0807 mL	0.4036 mL	0.8072 mL	2.0179 mL
	20 mM	0.0605 mL	0.3027 mL	0.6054 mL	1.5134 mL
	25 mM	0.0484 mL	0.2422 mL	0.4843 mL	1.2108 mL
	30 mM	0.0404 mL	0.2018 mL	0.4036 mL	1.0090 mL
	40 mM	0.0303 mL	0.1513 mL	0.3027 mL	0.7567 mL
	50 mM	0.0242 mL	0.1211 mL	0.2422 mL	0.6054 mL
	60 mM	0.0202 mL	0.1009 mL	0.2018 mL	0.5045 mL