2. GPCR/G Protein
  3. Amylin Receptor
  4. Petrelintide

Petrelintide (ZP8396) is a dual amylin and calcitonin receptor agonist (DACRA) Petrelintide elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Petrelintide can be utilized in diabetes research.

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Custom Peptide Synthesis

Petrelintide

Petrelintide 화학구조

CAS No. : 2766385-23-1

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

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고객리뷰

Based on 1 Customer Validation

Other Forms of Petrelintide:

Petrelintide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • 순도&문서

  • References

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제품 설명

Petrelintide (ZP8396) is a dual amylin and calcitonin receptor agonist (DACRA) Petrelintide elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Petrelintide can be utilized in diabetes research[1][2][3][4].

IC50 & Target[1]

hAMY3R

2.997 nM (EC50)

hCTR

9.215 nM (EC50)

In Vitro

Petrelintide demonstrates agonistic activity against hAMY3R and hCTR in HEK-293 cells, with EC50 of 2.997 and 9.215 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Petrelintide Related Antibodies
Parmacokinetics
Species Dose Route T1/2 Tmax Cmax AUC0-t AUC0-∞
Rat[1] 1 mg/kg s.c. 26.2 h 24 h 4850 ng/mL 254046 ng·h/mL 286517 ng·h/mL
In Vivo

Petrelintide (0.04 mg/kg, s.c., every third day for a total of 10 doses) reduces body weight and food intake in DIO rats[1].
Petrelintide (2 nmol/kg, s.c., every second day for 30 days, or 10 nmol/kg, s.c., every fourth day for 30 days) reduces food intake and body weight in DIO rats primarily by lowering intake of high fat diet[2].
Petrelintide (2 nmol/kg, s.c., every second day for 30 days, or 10 nmol/kg, s.c., every fourth day for 30 days) shows preferential fat mass loss and preservation of relative lean mass during weight loss in DIO rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DIO rats[1]
Dosage: 0.04 mg/kg
Administration: s.c., every third day for a total of 10 doses
Result: Significantly reduced body weight and food intake compared to the vehicle group.
Animal Model: DIO rats[2]
Dosage: 2, 10 nmol/kg
Administration: s.c., every second day (2 nmol/kg) or every fourth day (10 nmol/kg) for 30 days
Result: Resulted in significant lower relative body weight compared to vehicle.
Resulted in significant reduction of total cumulative intake of high fat diet compared to vehicle.
Exhibited no change in total cumulative intake of chow compared to vehicle.
Animal Model: DIO rats[3]
Dosage: 2, 10 nmol/kg
Administration: s.c., every second day (2 nmol/kg) or every fourth day (10 nmol/kg) for 30 days
Result: Resulted in significantly lower relative body weight compared to vehicle.
Resulted in significant reduction of fat mass in comparison to vehicle.
Resulted in significant preservation of relative lean mass in comparison to vehicle.
분자량

4191.69

화학식

C185H305N49O61
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{γGlu-arachidate}-Arg-Asp-Gly-Thr-Ala-Thr-Lys-Ala-Thr-Glu-Arg-Leu-Ala-{homoGlu}-Phe-Leu-Gln-Arg-Ser-Ser-Phe-{Sar}-Ala{NMeIle}-Leu-Ser-Ser-Thr-Glu-Val-Gly-Ser-Asn-Thr-{Hyp}-NH2 (Lactm bridge:Asp3-Lys8)
Sequence Shortening

{γGlu-arachidate}-RDGTATKATERLA-{homoGlu}-FLQRSSF-{Sar}-A{NMeIle}-LSSTEVGSNT-{Hyp}-NH2 (Lactm bridge:Asp3-Lys8)
선적

Room temperature in continental US; may vary elsewhere.
보관

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도
In Vitro: 

DMSO : 25 mg/mL (5.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2386 mL 1.1928 mL 2.3857 mL
5 mM 0.0477 mL 0.2386 mL 0.4771 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (0.60 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (0.60 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서

Purity: 99.49%

SDS (252 KB)

COA (275 KB) RP-HPLC (267 KB) MS (70 KB) Elemental Analysis Report (131 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2386 mL 1.1928 mL 2.3857 mL 5.9642 mL
5 mM 0.0477 mL 0.2386 mL 0.4771 mL 1.1928 mL
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Petrelintide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Petrelintide2766385-23-1ZP8396ZP 8396ZP-8396Amylin ReceptorAMYRdiet-induced obese (DIO) ratsdiabetesInhibitorinhibitorinhibit

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상품명:
Petrelintide
Cat. No.:
HY-P10745
수량:
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SAFETY DATA SHEET (SDS)

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