PF-03654746 Tosylate

Name: PF-03654746 Tosylate
Brand: MedChemExpress
SKU: HY-11044
Rating: 4.5 (0 reviews)

製品番号: HY-11044 純度: 99.1%: Data Sheet SDS COA 取扱説明書
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PF-03654746 Tosylate is a potent, selective and brain-penetrant histamine H3 receptor antagonist. PF-03654746 Tosylate reduces allergen-induced nasal symptoms. PF-03654746 Tosylate has potential for treatment of human cognitive disorders, improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

PF-03654746 Tosylate 構造式

CAS 番号 : 1039399-17-1

容量	価格（税別）	在庫状況	数量
1 mg	$150	在庫あり	Estimated Time of Arrival: December 31
5 mg		お問い合わせ
10 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of PF-03654746 Tosylate:

PF-03654746 お問い合わせ

Histamine Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

PF-03654746 Tosylate is a potent, selective and brain-penetrant histamine H3 receptor antagonist. PF-03654746 Tosylate reduces allergen-induced nasal symptoms^[1]. PF-03654746 Tosylate has potential for treatment of human cognitive disorders, improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)^[2].

IC₅₀ & Target

H₃ receptor

臨床実験

分子量

494.59

分子式

C₂₅H₃₂F₂N₂O₄S

CAS 番号

1039399-17-1

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1C[C@](C1)(F)C2=CC=C(CN3CCCC3)C(F)=C2)NCC.O=S(C4=CC=C(C)C=C4)(O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

H₂O : 8.4 mg/mL (16.98 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0219 mL	10.1094 mL	20.2188 mL
5 mM	0.4044 mL	2.0219 mL	4.0438 mL
10 mM	0.2022 mL	1.0109 mL	2.0219 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.65%

Select Batch:

データシート (270 KB) SDS (252 KB)

COA (245 KB) LCMS (144 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Stokes JR, et al. The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2. [Content Brief]

[2]. Brioni JD, et al. Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46. [Content Brief]

[3]. Wager TT, et, al. Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764). J Med Chem. 2011 Nov 10;54(21):7602-20. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.0219 mL	10.1094 mL	20.2188 mL	50.5469 mL
	5 mM	0.4044 mL	2.0219 mL	4.0438 mL	10.1094 mL
	10 mM	0.2022 mL	1.0109 mL	2.0219 mL	5.0547 mL
	15 mM	0.1348 mL	0.6740 mL	1.3479 mL	3.3698 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.