2. Neuronal Signaling
  3. Beta-secretase
  4. PF-06663195

PF-06663195 is a β-secretase (BACE1) inhibitor, with BACE1 CFA and BACE1 WCA IC50 values of 53 and 15 nM, respectively. PF-06663195 can be used for Alzheimer's disease research.

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PF-06663195

PF-06663195 화학구조

CAS No. : 1621585-22-5

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PF-06663195 Related Antibodies

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제품 설명

PF-06663195 is a β-secretase (BACE1) inhibitor, with BACE1 CFA and BACE1 WCA IC50 values of 53 and 15 nM, respectively. PF-06663195 can be used for Alzheimer's disease research[1].

Cellular Effect
Cell Line Type Value Description References
CHO IC50
10.1 μM
Compound: 13
Inhibition of human ERG expressed in CHO cells
Inhibition of human ERG expressed in CHO cells
[PMID: 25781223]
H4 IC50
53 nM
Compound: 13
Inhibition of BACE1 in human H4 cells overexpressing wild type human APP695 assessed as colorimetric reaction by Whole cell assay
Inhibition of BACE1 in human H4 cells overexpressing wild type human APP695 assessed as colorimetric reaction by Whole cell assay
[PMID: 25781223]
분자량

397.41

화학식

C18H18F3N3O2S
CAS No.
SMILES

FC[C@@H]1[C@@]2([H])[C@](N=C(S1)N)(C3=C(C=C(C=C3)F)F)CO[C@@H](C4=CC(C)=NO4)C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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PF-06663195 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-066631951621585-22-5PF06663195PF 06663195Beta-secretaseBACEβ-SecretaseAlzheimer's diseaseBACE1 CFAInhibitorinhibitorinhibit

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상품명:
PF-06663195
Cat. No.:
HY-138013
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