2. Protein Tyrosine Kinase/RTK
  3. ROS Kinase
  4. Pinealon

Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia.

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Pinealon

Pinealon 構造式

CAS 番号 : 175175-23-2

容量 価格（税別） 在庫状況 数量
25 mg $37 在庫あり
50 mg $60 在庫あり
100 mg $95 在庫あり
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500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Pinealon 関連抗体

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製品説明

Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia[1][2][3].

体外実験

Pinealon (10, 50, 100 nM; 30 min) in a dose-dependent manner prevents an increase in the ROS accumulation induced by ouabain in cerebellar granule cells[1].
Pinealon (10 nM; 0, 2.5, 5, 10, 20, 30 min) suppresses the activation of ERK 1/2 in rat cerebellar granule cells exposed to 500 mM homo-cysteine (HC)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pinealon 関連抗体
体内実験

Pinealon (50, 100, 200 ng/kg; Injection, for 5 days) shows a dose-dependent effect on the maintenance of a previously acquired skill in rats[2].
Pinealon (10 µg/kg; daily for 5 days) protects the rat offspring from prenatal hyperhomocysteinemia[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 200-250 g, white male rats[2]
Dosage: 50, 100, 200 ng/kg
Administration: Injection; for 5 days
Result: Showed dose-dependent effects on the maintenance of a previously acquired skill in the Morris maze.
Animal Model: 180-200 g, Female Wistar rats[3]
Dosage: 10 µg/kg
Administration: I.p.; daily for 5 days
Result: Protected the rat offspring from prenatal hyperhomocysteinemia.
分子量

418.40

分子式

C15H26N6O8
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence Shortening

EDR
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : ≥ 100 mg/mL (239.01 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3901 mL 11.9503 mL 23.9006 mL
5 mM 0.4780 mL 2.3901 mL 4.7801 mL
10 mM 0.2390 mL 1.1950 mL 2.3901 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.3901 mL 11.9503 mL 23.9006 mL 59.7514 mL
5 mM 0.4780 mL 2.3901 mL 4.7801 mL 11.9503 mL
10 mM 0.2390 mL 1.1950 mL 2.3901 mL 5.9751 mL
15 mM 0.1593 mL 0.7967 mL 1.5934 mL 3.9834 mL
20 mM 0.1195 mL 0.5975 mL 1.1950 mL 2.9876 mL
25 mM 0.0956 mL 0.4780 mL 0.9560 mL 2.3901 mL
30 mM 0.0797 mL 0.3983 mL 0.7967 mL 1.9917 mL
40 mM 0.0598 mL 0.2988 mL 0.5975 mL 1.4938 mL
50 mM 0.0478 mL 0.2390 mL 0.4780 mL 1.1950 mL
60 mM 0.0398 mL 0.1992 mL 0.3983 mL 0.9959 mL
80 mM 0.0299 mL 0.1494 mL 0.2988 mL 0.7469 mL
100 mM 0.0239 mL 0.1195 mL 0.2390 mL 0.5975 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Pinealon Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pinealon175175-23-2ROS KinaseInhibitorinhibitorinhibit

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