175175-23-2
175175-23-2
Chemical Structure
Pinealon
- CAS No.: 175175-23-2
- Formula:C15H26N6O8
- Molecular Weight:418.40
InChIKey: QPRZKNOOOBWXSU-CIUDSAMLSA-N
SMILES: O=C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)[C@H](CCC(O)=O)N
Biological Activity: Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pinealon | 99.51% | Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. | ||||||||||||||||||||
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Thymotrinan | Thymotrinan (RGH-0205) is a biologically active fragment of the naturally occurring thymus hormone thymopoietin and a immunomodulating peptide. Thymotrinan exerts similar immunomodulatory activities to TP5 and to affect humoral as well as cellular responses. | |||||||||||||||||||||
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Arg-Gly-Asp-Ser (Standard) | ≥98% | Arg-Gly-Asp-Ser (Standard) is the analytical standard of Arg-Gly-Asp-Ser. This product is intended for research and analytical applications. Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1. | ||||||||||||||||||||
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Glu-Arg | Glu-Arg is a dipeptide linked by L-glutamic acid and L-arginine. Glu-Arg contributes to the construction of the hydrophobic network and maintenance of stability of mouse cAMP-dependent protein kinase; it acts as a core hub connecting the activation segment and the GHI subdomain in eukaryotic protein kinases, and promotes signal transmission between elements and within enzymes. As a salt bridge, Glu-Arg regulates the formation and unfolding rates of α-helices, and its optimized spatial conformation is conducive to the stability and folding rate of α-helices. Glu-Arg induces concentration-dependent intracellular calcium changes in cultured human fungiform taste bud cells. | |||||||||||||||||||||
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Arg-Gly-Glu-Ser | Arg-Gly-Glu-Ser is a polypeptide related to RGD and is a negative control for Arg-Gly-Asp-Ser (HY-12290). | |||||||||||||||||||||
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Arg-Gly-Asp-Cys | Arg-Gly-Asp-Cys is the binding motif of fibronectin to cell adhesion molecules, and can inhibit platelet aggregation and fibrinogen binding. | |||||||||||||||||||||
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Cardiogen | Cardiogen is a short biologically active peptide (Ala-Glu-Asp-Arg) that does not bind single-stranded deoxyribooligonucleotides, slightly quenches fluorescence of some double-stranded deoxyribooligonucleotides, strongly quenches fluorescence of methylated and unmethylated λ phage DNA-ethidium bromide complexes. | |||||||||||||||||||||
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RGDV | RGDV is a platelet aggregation inhibitor. RGDV inhibits platelet-dependent thrombus formation. RGDV is used for tumor recognition via the targeting effect. | |||||||||||||||||||||
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SDGR | SDGR is a Ser-Asp-Gly-Arg tetrapeptide sequence that effectively inhibits fibronectin-mediated cell attachment | |||||||||||||||||||||
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RGDT | RGDT is a synthetic peptide. RGDT can be used in the research of cancer. | |||||||||||||||||||||
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REDV | 99.91% | REDV is the minimal active sequence within the CS5 site of the alternatively spliced type III connecting segment (IIICS) region of fibronectin. REDV can mediate adhesion to the IIICS region of plasma fibronectin by binding the integrin alpha 4 beta 1(α4β1). REDV can be used for the research of cell adhesion. REDV is used to study the effects of gene vectors containing REDV on cells. | ||||||||||||||||||||
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References
- [1]. Khavinson V, et al. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res. 2011 Oct;14(5):535-41. [Content Brief]
- [2]. G. V. Karantysh, et al. Effect of Pinealon on Learning and Expression of NMDA Receptor Subunit Genes in the Hippocampus of Rats with Experimental Diabetes. Neurochemical Journal, 2020, 14, 314-320.
- [3]. Arutjunyan A, et al. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med. 2012;5(2):179-85. [Content Brief]
