2. Protein Tyrosine Kinase/RTK
  3. ROS Kinase
  4. Pinealon

Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia.

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Synthèse de peptides personnalisée

Pinealon

Pinealon Chemical Structure

CAS No. : 175175-23-2

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Pinealon Related Antibodies

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Description

Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia[1][2][3].

In Vitro

Pinealon (10, 50, 100 nM; 30 min) in a dose-dependent manner prevents an increase in the ROS accumulation induced by ouabain in cerebellar granule cells[1].
Pinealon (10 nM; 0, 2.5, 5, 10, 20, 30 min) suppresses the activation of ERK 1/2 in rat cerebellar granule cells exposed to 500 mM homo-cysteine (HC)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pinealon Related Antibodies
In Vivo

Pinealon (50, 100, 200 ng/kg; Injection, for 5 days) shows a dose-dependent effect on the maintenance of a previously acquired skill in rats[2].
Pinealon (10 µg/kg; daily for 5 days) protects the rat offspring from prenatal hyperhomocysteinemia[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 200-250 g, white male rats[2]
Dosage: 50, 100, 200 ng/kg
Administration: Injection; for 5 days
Result: Showed dose-dependent effects on the maintenance of a previously acquired skill in the Morris maze.
Animal Model: 180-200 g, Female Wistar rats[3]
Dosage: 10 µg/kg
Administration: I.p.; daily for 5 days
Result: Protected the rat offspring from prenatal hyperhomocysteinemia.
Masse moléculaire

418.40

Formule

C15H26N6O8
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

EDR
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité
In Vitro: 

H2O : ≥ 100 mg/mL (239.01 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3901 mL 11.9503 mL 23.9006 mL
5 mM 0.4780 mL 2.3901 mL 4.7801 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.3901 mL 11.9503 mL 23.9006 mL 59.7514 mL
5 mM 0.4780 mL 2.3901 mL 4.7801 mL 11.9503 mL
10 mM 0.2390 mL 1.1950 mL 2.3901 mL 5.9751 mL
15 mM 0.1593 mL 0.7967 mL 1.5934 mL 3.9834 mL
20 mM 0.1195 mL 0.5975 mL 1.1950 mL 2.9876 mL
25 mM 0.0956 mL 0.4780 mL 0.9560 mL 2.3901 mL
30 mM 0.0797 mL 0.3983 mL 0.7967 mL 1.9917 mL
40 mM 0.0598 mL 0.2988 mL 0.5975 mL 1.4938 mL
50 mM 0.0478 mL 0.2390 mL 0.4780 mL 1.1950 mL
60 mM 0.0398 mL 0.1992 mL 0.3983 mL 0.9959 mL
80 mM 0.0299 mL 0.1494 mL 0.2988 mL 0.7469 mL
100 mM 0.0239 mL 0.1195 mL 0.2390 mL 0.5975 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Pinealon Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pinealon175175-23-2ROS KinaseInhibitorinhibitorinhibit

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