PNR-3-82 

PNR-3-82 is a highly selective inhibitor of endonuclease G (EndoG) with an IC₅₀ value of 0.61 μM against EndoG. As a non-competitive inhibitor, PNR-3-82 blocks EndoG-mediated DNA fragmentation. PNR-3-82 enhances the in vivo delivery efficiency of plasmid DNA and exhibits bioprotective effects against drug-related injuries and other cell/tissue damages. PNR-3-82 can be used in studies related to prostate cancer^[1].

PNR-3-82 potently inhibits recombinant mouse and human EndoG with an IC₅₀ of 0.61 μM, acting as an uncompetitive inhibitor^[1].
PNR-3-82 (1 μM; 1 h) inhibits recombinant mouse and human EndoG-mediated plasmid DNA degradation in a plasmid incision assay^[1].
PNR-3-82 exhibits high specificity for EndoG, is inactive against DNase II, and has no inhibitory effect on RNase A, proteases, LDH, or SOD1^[1].
PNR-3-82 (50 μM; 2 h pre-incubation, followed by 24 h co-incubation with cisplatin) reduces Cisplatin (HY-17394)-induced cell death in natural EndoG-expressing 22Rv1 human prostate carcinoma cells^[1].
PNR-3-82 (50 μM; 2 h pre-incubation, followed by 24 h co-incubation with docetaxel) reduces Docetaxel (HY-B0011)-induced cell death and DNA fragmentation in EndoG-overexpressing PC3 human prostate adenocarcinoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

455.49

C₂₅H₁₇N₃O₄S

1424353-64-9

Solid

Orange to red

O=C1NC(NC(/C1=C\C2=CN(C3=C2C=C(OC)C=C3)C(C4=CC5=C(C=CC=C5)C=C4)=O)=O)=S

Room temperature in continental US; may vary elsewhere.

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

• [1]. Jang DS, et al. Novel cytoprotective inhibitors for apoptotic endonuclease G. DNA Cell Biol. 2015;34(2):92-100.  [Content Brief]