1424353-64-9
Chemical Structure
PNR-3-82
- CAS No.: 1424353-64-9
- Formula:C25H17N3O4S
- Molecular Weight:455.49
IUPAC Name: 5-((1-(2-naphthoyl)-5-methoxy-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
InChIKey: GCPQISXOFXGFJM-UHFFFAOYSA-N
SMILES: O=C1NC(NC(/C1=C\C2=CN(C3=C2C=C(OC)C=C3)C(C4=CC5=C(C=CC=C5)C=C4)=O)=O)=S
Biological Activity: PNR-3-82 is a highly selective inhibitor of endonuclease G (EndoG) with an IC50 value of 0.61 μM against EndoG. As a non-competitive inhibitor, PNR-3-82 blocks EndoG-mediated DNA fragmentation. PNR-3-82 enhances the in vivo delivery efficiency of plasmid DNA and exhibits bioprotective effects against drug-related injuries and other cell/tissue damages. PNR-3-82 can be used in studies related to prostate cancer[1].
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PNR-3-82 | 99.08% | PNR-3-82 is a highly selective inhibitor of endonuclease G (EndoG) with an IC50 value of 0.61 μM against EndoG. As a non-competitive inhibitor, PNR-3-82 blocks EndoG-mediated DNA fragmentation. PNR-3-82 enhances the in vivo delivery efficiency of plasmid DNA and exhibits bioprotective effects against drug-related injuries and other cell/tissue damages. PNR-3-82 can be used in studies related to prostate cancer. | ||||||||||||||||||||
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Keywords
