Polyaminopropyl biguanide  (Synonyms: PAPB)

Polyaminopropyl biguanide (PAPB) is a positively charged antimicrobial polymer and cosmetic preservative. Polyaminopropyl biguanide inhibits the growth and division of negatively charged microorganisms via charge-based adsorption. Polyaminopropyl biguanide exhibits broad-spectrum in vitro activity against foodborne microorganisms and postharvest fruit pathogens. Polyaminopropyl biguanide can be used in studies related to citrus postharvest diseases and foodborne bacterial infections^[2].

Polyaminopropyl biguanide (0.125-0.25%) significantly enhances the tensile strength and elongation at break of PEC/PVA composite films, with the 0.25% formulation exhibiting the highest tensile strength of up to 26.90 MPa^[2].
Polyaminopropyl biguanide (0.125-1%) reduces the diffraction peak intensity of PEC/PVA composite films and improves their thermal stability in a concentration-dependent manner^[2].
The polyaminopropyl biguanide/PEC/PVA composite films (0.125-1%) exhibit potent in vitro antibacterial activity, including 100% inhibition of Penicillium italicum at a polyaminopropyl biguanide concentration of 0.125%, and show stronger activity against Staphylococcus aureus than against Escherichia coli^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(C₅H₁₄N₆)_n

133029-32-0

Solid

White to off-white

N=C(NC(NCCCN)=N)N.[n]

Room temperature in continental US; may vary elsewhere.

• [1]. Scientific Committee on Consumer Safety; Bernauer U. Opinion of the scientific committee on consumer safety (SCCS)--2nd Revision of the safety of the use of poly(hexamethylene) biguanide hydrochloride or polyaminopropyl biguanide (PHMB) in cosmetic products. Regul Toxicol Pharmacol. 2015 Dec;73(3):885-6.  [Content Brief]

  [2]. He M, et al. Fabrication of antimicrobial packaging based on polyaminopropyl biguanide incorporated pectin/polyvinyl alcohol films for fruit preservation. Food Chem. 2024;457:140106.  [Content Brief]