Pradofloxacin 

Pradofloxacin, a third-generation fluoroquinolone antibacterial agent. Pradofloxacin can be used for the study of bacterial infections in the dog and cat, such as skin infections^[1].

In cats, after oral dosing of Pradofloxacin at 24-h intervals, formulated as an oral suspension, at three dose rates (2.5, 5.0 and 10.0 mg/kg) for a total of five administrations, dose-dependent Cmax values of 0.9-3.2 μg/mL were achieved rapidly within 0.5-1.0 h. Terminal half-life (7.2-9.8 h) and mean residence time (8.8 h) were of medium duration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

396.41

C₂₁H₂₁FN₄O₃

195532-12-8

Solid

Light yellow to yellow

N#CC1=C2N(C3CC3)C=C(C(C2=CC(F)=C1N4C[C@@]5([H])[C@@](NCCC5)([H])C4)=O)C(O)=O

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Lees P. Pharmacokinetics, pharmacodynamics and therapeutics of pradofloxacin in the dog and cat. J Vet Pharmacol Ther. 2013 Jun;36(3):209-21.  [Content Brief]