Pralidoxime

Cat. No.: HY-B1738: Data Sheet
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SDS
Handling Instructions
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Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Pralidoxime chloride and Pralidoxime iodide) usually boasts enhanced water solubility and stability.

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Pralidoxime 화학구조

CAS No. : 6735-59-7

사이즈	가격	재고
1 mg		Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Pralidoxime:

Pralidoxime chloride Pralidoxime iodide

Other Forms of Pralidoxime:

2 Publications Citing Use of MCE Pralidoxime

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AChE BChE

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

AChE

In Vivo

Pralidoxime (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	F1B6D2 mice (male, administered subcutaneously diethylparaoxon)^[3]
Dosage:	10, 50, 100, and 150 mg/kg
Administration:	Intramuscular administration, once
Result:	Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.

Clinical Trial

분자량

137.16

화학식

C₇H₉N₂O⁺

CAS No.

6735-59-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

C[N+]1=CC=CC=C1/C=N/O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

순도&문서

Purity: ≥90.0%

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Data Sheet (269 KB) SDS (251 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141. [Content Brief]

[2]. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111. [Content Brief]

[3]. Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46(2):131‐138. [Content Brief]

Pralidoxime Related Classifications

Neurological Disease

몰농도 계산기
농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pralidoxime6735-59-7Cholinesterase (ChE)reactivatordiethylparaoxonpralidoximeplethymosgraphyorganophosphatesnerve agentorganophosphorusInhibitorinhibitorinhibit

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