2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Pralidoxime

Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Pralidoxime chloride and Pralidoxime iodide) usually boasts enhanced water solubility and stability.

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Pralidoxime

Pralidoxime 構造式

CAS 番号 : 6735-59-7

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Pralidoxime 関連抗体

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製品説明

Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning[1][2].

IC50 & Target

AChE

 

体内実験

Pralidoxime (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: F1B6D2 mice (male, administered subcutaneously diethylparaoxon)[3]
Dosage: 10, 50, 100, and 150 mg/kg
Administration: Intramuscular administration, once
Result: Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.
臨床実験
分子量

137.16

分子式

C7H9N2O+
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

C[N+]1=CC=CC=C1/C=N/O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
純度とドキュメンテーション

純度: ≥90.0%

COA (246 KB)

取扱説明書 (2659 KB)
参考文献
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Pralidoxime Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pralidoxime6735-59-7Cholinesterase (ChE)reactivatordiethylparaoxonpralidoximeplethymosgraphyorganophosphatesnerve agentorganophosphorusInhibitorinhibitorinhibit

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製品名:
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製品番号:
HY-B1738
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