2. GPCR/G Protein
  3. Amylin Receptor
  4. Pramlintide acetate

Pramlintide acetate is a polypeptide analogue of human amylin. Pramlintide acetate, an antidiabetic agent, is antineoplastic in colorectal cancer.

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Pramlintide acetate

Pramlintide acetate Estructura química

No. CAS : 187887-46-3

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Other Forms of Pramlintide acetate:

Pramlintide acetate Related Antibodies

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Descripciòn

Pramlintide acetate is a polypeptide analogue of human amylin. Pramlintide acetate, an antidiabetic agent, is antineoplastic in colorectal cancer[1].

In Vitro

Pramlintide inhibits the growth of HCT-116 and HT-29 in a dose-dependent manner, with higher efficacy against the latter (IC50s of 48.67 and 9.10 μg/mL, respectively)[1].
? The addition of 5, 10, and 20 μg/mL of Pramlintide to HCT-116 and HT-29 with 5-fluorouracil, Oxaliplatin, or Irinotecan induces the antiproliferative effect synergistically[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pramlintide acetate Related Antibodies
Peso molecular

3949.39 (free base)

Fòrmula

C171H267N51O53S2.xC2H4O2
No. CAS
Appearance

Solid

Color

White to off-white

Sequence

Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide bridge:Cys2-Cys7)
Sequence Shortening

KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY-NH2 (Disulfide bridge:Cys2-Cys7)
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

H2O : 50 mg/mL (ultrasonic and adjust pH to 3 with CH3COOH)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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Pureza y Documentación

Purity: 99.97%

SDS (420 KB)

COA (272 KB) RP-HPLC (263 KB) MS (74 KB)

Instrucciones de manejo (2659 KB)
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Pramlintide acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pramlintide187887-46-3Amylin ReceptorAMYRamylinantidiabeticantineoplasticcolorectalcancerInhibitorinhibitorinhibit

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Nombre del producto:
Pramlintide acetate
Cat. No.:
HY-P0058B
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