Pramlintide (acetate)

Name: Pramlintide acetate
Brand: MedChemExpress
SKU: HY-P0058B
Rating: 4.5 (0 reviews)

製品番号: HY-P0058B 純度: 99.97%: Data Sheet SDS COA 取扱説明書
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Pramlintide acetate is a polypeptide analogue of human amylin. Pramlintide acetate, an antidiabetic agent, is antineoplastic in colorectal cancer.

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Pramlintide (acetate) 構造式

CAS 番号 : 187887-46-3

容量	価格（税別）	在庫状況	数量
5 mg	$180	在庫あり	Estimated Time of Arrival: December 31
10 mg	$280	在庫あり	Estimated Time of Arrival: December 31
25 mg	$600	在庫あり	Estimated Time of Arrival: December 31
50 mg	$960	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1550	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of Pramlintide acetate:

Pramlintide acetate hydrate 在庫あり
Pramlintide 在庫あり
Pramlintide-(Ala-¹³C₃,¹⁵N) お問い合わせ
Pramlintide TFA お問い合わせ

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純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Pramlintide acetate is a polypeptide analogue of human amylin. Pramlintide acetate, an antidiabetic agent, is antineoplastic in colorectal cancer^[1].

体外実験

Pramlintide inhibits the growth of HCT-116 and HT-29 in a dose-dependent manner, with higher efficacy against the latter (IC₅₀s of 48.67 and 9.10 μg/mL, respectively)^[1].
? The addition of 5, 10, and 20 μg/mL of Pramlintide to HCT-116 and HT-29 with 5-fluorouracil, Oxaliplatin, or Irinotecan induces the antiproliferative effect synergistically^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

3949.39 (free base)

分子式

C₁₇₁H₂₆₇N₅₁O₅₃S₂.xC₂H₄O₂

CAS 番号

187887-46-3

Appearance

Solid

Color

White to off-white

Sequence

Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide bridge:Cys2-Cys7)

Sequence Shortening

KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY-NH2 (Disulfide bridge:Cys2-Cys7)

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Sealed storage, away from moisture
Powder	-80°C	2 years
	-20°C	1 year
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

H₂O : 50 mg/mL (ultrasonic and adjust pH to 3 with CH3COOH)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.97%

Select Batch:

データシート (287 KB) SDS (420 KB)

COA (272 KB) RP-HPLC (263 KB) MS (74 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Maha S Al-Keilani, et al. Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy. Clin Pharmacol. 2018 Mar 5;10:23-29. [Content Brief]