2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Propargyl-PEG3-acid

Propargyl-PEG3-acid  (Synonyms: プロパルギル-PEG3-カルボン酸)

製品番号: HY-126975 純度: 99.14%
COA 取扱説明書 Technical Support

Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA (HY-B1081, HY-B1081A) and Propargyl-PEG3-acid. Propargyl-PEG3-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Propargyl-PEG3-acid

Propargyl-PEG3-acid 構造式

CAS 番号 : 1347760-82-0

容量 価格（税別） 在庫状況 数量
100 mg $28 在庫あり
250 mg $67 在庫あり
1 g $260 在庫あり
5 g $865 在庫あり
10 g   お問い合わせ  
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Propargyl-PEG3-acid 関連抗体

Top Publications Citing Use of Products

ADC Linker アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

PROTAC Linkers アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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製品説明

Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA (HY-B1081, HY-B1081A) and Propargyl-PEG3-acid[1]. Propargyl-PEG3-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PEGs

 

Non-cleavable Linker

 

体外実験

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propargyl-PEG3-acid 関連抗体
分子量

216.23

分子式

C10H16O5
CAS 番号
Appearance

Liquid (Density: 1.131±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(O)CCOCCOCCOCC#C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (462.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6247 mL 23.1235 mL 46.2471 mL
5 mM 0.9249 mL 4.6247 mL 9.2494 mL
10 mM 0.4625 mL 2.3124 mL 4.6247 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.14%

COA (241 KB) HNMR (118 KB) GC (181 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6247 mL 23.1235 mL 46.2471 mL 115.6176 mL
5 mM 0.9249 mL 4.6247 mL 9.2494 mL 23.1235 mL
10 mM 0.4625 mL 2.3124 mL 4.6247 mL 11.5618 mL
15 mM 0.3083 mL 1.5416 mL 3.0831 mL 7.7078 mL
20 mM 0.2312 mL 1.1562 mL 2.3124 mL 5.7809 mL
25 mM 0.1850 mL 0.9249 mL 1.8499 mL 4.6247 mL
30 mM 0.1542 mL 0.7708 mL 1.5416 mL 3.8539 mL
40 mM 0.1156 mL 0.5781 mL 1.1562 mL 2.8904 mL
50 mM 0.0925 mL 0.4625 mL 0.9249 mL 2.3124 mL
60 mM 0.0771 mL 0.3854 mL 0.7708 mL 1.9270 mL
80 mM 0.0578 mL 0.2890 mL 0.5781 mL 1.4452 mL
100 mM 0.0462 mL 0.2312 mL 0.4625 mL 1.1562 mL
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Propargyl-PEG3-acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propargyl-PEG3-acid1347760-82-0ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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製品名:
Propargyl-PEG3-acid
製品番号:
HY-126975
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