2. Apoptosis Autophagy Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Apoptosis Autophagy Reactive Oxygen Species (ROS)
  4. Pyridinium bisretinoid A2E

Pyridinium bisretinoid A2E (A2E) is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E can be used in the study of retinal degenerative diseases.

It is advisable to consider the salt form (Pyridinium bisretinoid A2E TFA) that retains the same biological activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Pyridinium bisretinoid A2E

Pyridinium bisretinoid A2E 화학구조

CAS No. : 173449-96-2

사이즈 재고
50 mg   견적 받기  
100 mg   견적 받기  
250 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Pyridinium bisretinoid A2E:

Other Forms of Pyridinium bisretinoid A2E:

Pyridinium bisretinoid A2E Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Pyridinium bisretinoid A2E (A2E) is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E can be used in the study of retinal degenerative diseases[1][2].

In Vitro

Exposure of Pyridinium bisretinoid A2E (A2E) to light triggers its conversion into at least two products. One of these is epoxy-A2E, which is hydrophilic and can be transferred from the membrane to an aqueous solution. The other product is an unidentified hydrophobic substance[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pyridinium bisretinoid A2E Related Antibodies
분자량

592.92

화학식

C42H58NO+
CAS No.
SMILES

OCC[N+]1=CC=C(/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C=C1/C=C(C)/C=C/C=C(C)/C=C/C3=C(C)CCCC3(C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
용액&용해도
In Vitro: 

DMSO : 150 mg/mL (252.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6866 mL 8.4328 mL 16.8657 mL
5 mM 0.3373 mL 1.6866 mL 3.3731 mL
View the Complete Stock Solution Preparation Table

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6866 mL 8.4328 mL 16.8657 mL 42.1642 mL
5 mM 0.3373 mL 1.6866 mL 3.3731 mL 8.4328 mL
10 mM 0.1687 mL 0.8433 mL 1.6866 mL 4.2164 mL
15 mM 0.1124 mL 0.5622 mL 1.1244 mL 2.8109 mL
20 mM 0.0843 mL 0.4216 mL 0.8433 mL 2.1082 mL
25 mM 0.0675 mL 0.3373 mL 0.6746 mL 1.6866 mL
30 mM 0.0562 mL 0.2811 mL 0.5622 mL 1.4055 mL
40 mM 0.0422 mL 0.2108 mL 0.4216 mL 1.0541 mL
50 mM 0.0337 mL 0.1687 mL 0.3373 mL 0.8433 mL
60 mM 0.0281 mL 0.1405 mL 0.2811 mL 0.7027 mL
80 mM 0.0211 mL 0.1054 mL 0.2108 mL 0.5271 mL
100 mM 0.0169 mL 0.0843 mL 0.1687 mL 0.4216 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Pyridinium bisretinoid A2E Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyridinium bisretinoid A2E173449-96-2A2EApoptosisAutophagyReactive Oxygen Species (ROS)ROSblue-lightPhotoactivationInhibitorinhibitorinhibit

최근 본 상품:

온라인 문의

Your information is safe with us. * Required Fields.

상품명

  

Requested Quantity *

고객명 *

 

호칭

메일주소 *

 

전화번호 *

Department

 

회사명 *

City

도

Country or Region *

      

비고

대량구매 문의

Inquiry Information

상품명:
Pyridinium bisretinoid A2E
Cat. No.:
HY-134928
수량:
MCE Japan Authorized Agent:

고객리뷰

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

상품명

  

Lot #

고객명 *

 

메일주소 *

전화번호

 

Department *

회사명 *

 

Country or Region *

비고

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.