2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Quinelorane

Quinelorane (LY163502 free base) is a dopamine D2 receptor agonist. Quinelorane promotes semen ejaculation but inhibits penile erection in rats. Quinelorane can be used in the study of sexual dysfunction.

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Quinelorane

Quinelorane 화학구조

CAS No. : 97466-90-5

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Other Forms of Quinelorane:

Quinelorane Related Antibodies

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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제품 설명

Quinelorane (LY163502 free base) is a dopamine D2 receptor agonist. Quinelorane promotes semen ejaculation but inhibits penile erection in rats. Quinelorane can be used in the study of sexual dysfunction[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
1 nM
Compound: quinelorame
Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation
Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation
[PMID: 17976986]
CHO EC50
45 nM
Compound: Quinelorane
Agonist activity at human dopamine D2L receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS binding assay
Agonist activity at human dopamine D2L receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS binding assay
[PMID: 25490054]
CHO EC50
45 nM
Compound: Quinelorane
Agonist activity at human dopamine D2L receptor expressed in CHO cell membranes after 1 hr by [35S]-GTPgammaS binding assay
Agonist activity at human dopamine D2L receptor expressed in CHO cell membranes after 1 hr by [35S]-GTPgammaS binding assay
10.1039/C4MD00066H
Pituitary gland cell EC50
2 nM
Compound: quinelorame
Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accumulation
Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accumulation
[PMID: 17976986]
분자량

246.35

화학식

C14H22N4
CAS No.
SMILES

CCCN1[C@@]2([H])[C@@](CCC1)([H])CC3=NC(N)=NC=C3C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Quinelorane Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinelorane97466-90-5LY163502LY 163502LY-163502Dopamine ReceptorAgonistsSexual dysfunctionDopamine receptorsMedial preoptic areaInhibitorinhibitorinhibit

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상품명:
Quinelorane
Cat. No.:
HY-124521
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