(±)11(12)-EET (Synonyms: 11,12-EET)

Name: (±)11(12)-EET
Brand: MedChemExpress
SKU: HY-130494
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-130494 Reinheit: 98.3%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

(±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

(±)11(12)-EET Chemische Struktur

CAS. Nr. : 87173-81-7

Größe	Verfügbarkeit	Menge
Solvent
25 μg (312.04 μM * 250 μL in Ethanol)	Auf Lager	Estimated Time of Arrival: December 31
Solvent
50 μg (312.04 μM * 500 μL in Ethanol)	Auf Lager	Estimated Time of Arrival: December 31

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This product is a controlled substance and not for sale in your territory.

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Other Forms of (±)11(12)-EET:

(±)11(12)-EET-d₁₁ Angebot einholen

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle NOD-like Receptor (NLR) Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

NLRP3 NLRP1 NOD1 NOD2

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

(±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective^[1]^[2]^[3]^[4]^[6].

IC₅₀ & Target^[1]

NLRP3 inflammasome

In Vitro

(±)11(12)-EET (5 μM; 10 mimutes; macrophages) depresses NLRP3 protein expression, dramatically decreases the expression of pro-IL-1β in cells and the supernatant and reduces the intracellular ROS^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	Macrophages
Concentration:	5 μM
Incubation Time:	10 mimutes
Result:	Depresses NLRP3 protein expression.

Immunofluorescence^[1]

Cell Line:	Macrophages
Concentration:	5 μM
Incubation Time:	10 mimutes
Result:	Reduced the intracellular ROS.

In Vivo

(±)11(12)-EET increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 in 50 μg/kg^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

320.47

Formel

C₂₀H₃₂O₃

CAS. Nr.

87173-81-7

Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC/C=C\C[C@H]1O[C@H]1C/C=C\C/C=C\CCCC(O)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Solution, -20°C, 2 years

Reinheit & Dokumentation

Purity: 98.3%

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Data Sheet (271 KB) SDS (252 KB)

COA (247 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Luo XQ, et al. Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages. J Cell Physiol. 2020;235(12):9910-9921. [Content Brief]

[2]. Chacos N, et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun. 1982;104(3):916-922. [Content Brief]

[3]. Oliw EH, et al. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem. 1982;257(7):3771-3781. [Content Brief]

[4]. Capdevila JH, et al. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res. 2000;41(2):163-181. [Content Brief]

[5]. Wang Z, et al. Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways. Am J Physiol Renal Physiol. 2008;294(6):F1441-F1447. [Content Brief]

[6]. Spector AA. Arachidonic acid cytochrome P450 epoxygenase pathway. J Lipid Res. 2009;50 Suppl(Suppl):S52-S56. [Content Brief]

(±)11(12)-EET Related Classifications

Inflammation/Immunology Cardiovascular Disease

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)11(12)-EET87173-81-711,12-EETNOD-like Receptor (NLR)inflammasomeR/SenantiomericarachidoniccytochromeP450anti-inflammatoryangiogenicInhibitorinhibitorinhibit

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(±)11(12)-EET (Synonyms: 11,12-EET)

Kundenbewertung

Other Forms of (±)11(12)-EET:

(±)11(12)-EET Related Antibodies

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle NOD-like Receptor (NLR) Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

(±)11(12)-EET Related Antibodies

(±)11(12)-EET Related Classifications

Molaritätsrechner

Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

The dilution calculator equation

Keywords:

Ihre kürzlich angesehenen Produkte:

Kundenbewertung

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