2. TGF-beta/Smad
  3. TGF-β Receptor
  4. Ramatercept

Ramatercept  (Synonyms: ACE-031)

Art. -Nr.: HY-P99818 Reinheit: ≥99.0%
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Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy.

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CAS. Nr. : 1169766-01-1

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Ramatercept Related Antibodies

Top Publications Citing Use of Products

Alle TGF-β Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B BMP GDF15

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Beschreibung

Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy[1][2][3].

IC50 & Target

soluble activin receptor 2, ACVR2[2]
In Vivo

Ramatercept (ACE-031) (10 mg/kg; s.c.; three times a week for 5 weeks) significantly increases the muscle mass of mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Klinische Studie
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molekulargewicht

77.24 kDa

CAS. Nr.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ramatercept]
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • [ACVR2B (activin A receptor type 2B, ActR-IIB, ActRIIB)]2-IGHG1 Fc (Fragment constant)
Reinheit & Dokumentation
Verweise
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Ramatercept Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ramatercept1169766-01-1ACE-031ACE031ACE 031TGF-β ReceptorTransforming growth factor beta receptorsMuscle atrophyInhibitorinhibitorinhibit

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