2. Recombinant Proteins
  3. Cytokines and Growth Factors CD Antigens Biotinylated Proteins
  4. TNF Superfamily B Cell CD Proteins Macrophage CD Proteins
  5. TNF Superfamily Ligands CD257/BAFF
  6. B-cell Activating Factor (BAFF)
  7. BAFF/TNFSF13B Protein, Mouse (Biotinylated)

BAFF/TNFSF13B Protein, Mouse (Biotinylated)

Cat. No.: HY-P78792
Handling Instructions

BAFF/TNFSF13B protein binds to TNFRSF13B and TNFRSF17, stimulating B- and T-cell function and regulating humoral immunity. It also interacts with TNFSF13, promoting the survival and response of mature B-cells. Interestingly, BAFF/TNFSF13B isoform 2 inhibits isoform 1's secretion and bioactivity. BAFF/TNFSF13B Protein, Mouse (Biotinylated) is the recombinant mouse-derived BAFF/TNFSF13B protein, expressed by HEK293 , with tag free. The total length of BAFF/TNFSF13B Protein, Mouse (Biotinylated) is 183 a.a., with molecular weight of 20-25 kDa.

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Description

BAFF/TNFSF13B protein binds to TNFRSF13B and TNFRSF17, stimulating B- and T-cell function and regulating humoral immunity. It also interacts with TNFSF13, promoting the survival and response of mature B-cells. Interestingly, BAFF/TNFSF13B isoform 2 inhibits isoform 1's secretion and bioactivity. BAFF/TNFSF13B Protein, Mouse (Biotinylated) is the recombinant mouse-derived BAFF/TNFSF13B protein, expressed by HEK293 , with tag free. The total length of BAFF/TNFSF13B Protein, Mouse (Biotinylated) is 183 a.a., with molecular weight of 20-25 kDa.
Background

BAFF/TNFSF13B Protein is a cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA, forming a 2 ligands-2 receptors pathway that plays a crucial role in the stimulation of B- and T-cell function, as well as the regulation of humoral immunity. Additionally, BAFF/TNFSF13B interacts with TNFSF13/APRIL, which also binds to the same two receptors. The BAFF/TNFSF13B-BAFFR/BR3 interaction specifically promotes the survival of mature B-cells and enhances the overall B-cell response. Notably, isoform 2 of BAFF/TNFSF13B appears to inhibit the secretion and bioactivity of isoform 1.
Species

Mouse
Source

HEK293
Tag

Tag Free
Accession

Q9WU72 (A127-L309)
Gene ID

24099  [NCBI]
Molecular Construction
N-term
BAFF (A127-L309)
Accession # Q9WU72
C-term
Synonyms
TNFSF13B; BAFF; BLYS; CD257; DTL; TALL1; THANK; TNFSF20; ZTNF4; TALL-1
Molecular Weight

20-25 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

BAFF/TNFSF13B Protein, Mouse (Biotinylated) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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BAFF/TNFSF13B Protein, Mouse (Biotinylated)
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