1. Recombinant Proteins
  2. I-309/CCL1 Protein, Human

I-309/CCL1 Protein, Human

Cat. No.: HY-P7199
Handling Instructions

I-309/CCL1 Protein, Human attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8.

For research use only. We do not sell to patients.

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  • Technical Parameters

  • Properties

  • Documentation

Synonyms
rHuI-309/CCL1; C-C motif chemokine 1; SCYA1
Species

Human

Source

E. coli

Accession

P22362 (S23-K96)

Gene ID

6346

Molecular Weight

Approximately 8.5 kDa

AA Sequence

SKSMQVPFSRCCFSFAEQEIPLRAILCYRNTSSICSNEGLIFKLKRGKEACALDTVGWVQRHRKMLRHCPSKRK

Biological Activity
The ED50 is <1 μg/mL as measured by CHO-K1/Gα15/hCCR8 cells (human Gα15 and human CCR8 stably expressed in CHO-K1 cells).
Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against PBS.

Endotoxin Level

<0.2 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O or PBS.

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Background

Human I-309/CCL1 is a monocytec hemoattractant[1]. CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8. The CC chemokine I-309 is the only agonist that selectively induced intracellular Ca2+ mobilization and chemotaxis in receptor-transfected 300-19 cells. TER1 (ChemR1 or CKR-L1) is the receptor for I-309, and we propose to call this receptor CCR8 in agreement with the current nomenclature for chemokine receptors[2].

Documentation
References
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Product Name:
I-309/CCL1 Protein, Human
Cat. No.:
HY-P7199
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