IL-15R alpha & IL-15 Protein, Mouse (HEK293, His)

IL-15R alpha Protein, the high-affinity receptor for interleukin-15, crucially signals in cis and trans, presenting IL-15 to neighboring IL2RG-expressing cells. In neutrophils, it activates SYK kinase, essential for IL-15-induced phagocytosis in a SYK-dependent manner. IL-15R alpha forms a heterotrimer with IL2RB and IL2RG, capable of self-association. Interactions with SYK underscore its intricate involvement in cellular signaling pathways. IL-15R alpha & IL-15 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived IL-15R alpha & IL-15 protein, expressed by HEK293 , with C-His labeled tag. IL-15R alpha & IL-15 Protein, Mouse (HEK293, His), has molecular weight of ~36 kDa.

IL-15R alpha Protein emerges as the high-affinity receptor for interleukin-15, playing a crucial role in cellular signaling. This receptor exhibits the ability to signal both in cis and trans, where IL15R from one subset of cells presents interleukin-15 to neighboring IL2RG-expressing cells. In neutrophils, IL-15R alpha binds and activates the kinase SYK in response to interleukin-15 stimulation, and it is essential for IL-15-induced phagocytosis in a SYK-dependent manner. The interleukin-15 receptor, IL15R, forms a heterotrimer consisting of IL15RA, IL2RB, and IL2RG, with IL15RA capable of self-association (By similarity). Additionally, IL-15R alpha interacts with SYK, further highlighting its intricate involvement in cellular signaling pathways (By similarity).

Mouse

HEK293

C-His

Q60819-1 (G33-K205) & P48346 (G30-S162)

16169  [NCBI]&16168  [NCBI]

Approximately 17-23 kDa (IL-15) & 43-65 kDa (IL-15RA), based on SDS-PAGE under reducing conditions, due to the glycosylation.

≥ 95%, as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

• [1]. /biology-dictionary/efo-27-cell.html