Il15 - interleukin 15 Gene

Also Known as IL-15

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16168

About Il15

Chromosome 8: 83,058,261-83,129,851 reverse strand.GRCm39:CM001001.3

This gene has 10 transcripts (splice variants), 128 orthologues and is associated with 42 phenotypes. Broad expression in heart adult (RPKM 5.2), duodenum adult (RPKM 3.3) and 24 other tissues.

Summary

This gene encodes a a pleiotropic cytokine of the interleukin family of proteins that plays important roles in the innate and adaptive cell homeostasis, as well as peripheral immune function. The encoded protein undergoes proteolytic processing to generate a mature cytokine that stimulates the proliferation of natural killer cells. The transgenic mice overexpressing the encoded protein exhibit an increase in the number of memory CD8+ T cells in a naive state and enhanced protection against Bacterial infections. Mice lacking the encoded protein exhibit impaired protection against a strain of attenuated Mycobacterium. [provided by RefSeq, Aug 2016]

Il15 Products (2)

mRNA Protein Name
NM_001254747.2 NP_001241676.1 interleukin-15 preproprotein
NM_008357.3 NP_032383.1 interleukin-15 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
14607906 MGI
enables cytokine activity IMP
IMP: Inferred from mutant phenotype
10704459 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within NK T cell proliferation IMP
IMP: Inferred from mutant phenotype
10704459 MGI
acts upstream of or within cell maturation IGI
IGI: Inferred from genetic interaction
17318811 MGI
acts upstream of or within extrathymic T cell selection IMP
IMP: Inferred from mutant phenotype
10704459 MGI
acts upstream of or within lymph node development IMP
IMP: Inferred from mutant phenotype
10704459 MGI
acts upstream of natural killer cell differentiation IDA
IDA: Inferred from direct assay
14607906 MGI
acts upstream of natural killer cell differentiation IMP
IMP: Inferred from mutant phenotype
14607906 MGI
acts upstream of natural killer cell proliferation IDA
IDA: Inferred from direct assay
14607906 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
27684068 MGI
acts upstream of or within positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
10704459 MGI
acts upstream of or within positive regulation of immune response IMP
IMP: Inferred from mutant phenotype
10704459 MGI
acts upstream of or within positive regulation of natural killer cell differentiation IDA
IDA: Inferred from direct assay
14607906 MGI
acts upstream of or within positive regulation of natural killer cell differentiation IGI
IGI: Inferred from genetic interaction
17318811 MGI
acts upstream of or within positive regulation of natural killer cell differentiation IMP
IMP: Inferred from mutant phenotype
14607906 MGI
acts upstream of or within positive regulation of natural killer cell proliferation IDA
IDA: Inferred from direct assay
14607906 MGI
acts upstream of or within positive regulation of protein O-linked glycosylation IMP
IMP: Inferred from mutant phenotype
24509081 MGI
acts upstream of or within regulation of T cell differentiation IMP
IMP: Inferred from mutant phenotype
10704459 MGI
acts upstream of or within regulation of defense response to virus by host IMP
IMP: Inferred from mutant phenotype
10704459 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11737071 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il15 Protein Structure

IL15

IL15: cl03560 (32 - 153)

  • 0
  • 100
  • 162 a.a.
Protein Preferred Names Protein Names

interleukin-15

Recombinant Il15 Proteins

Cat. No. Product Name Accession Purity
HY-P78558 IL-15R alpha & IL-15 Protein, Mouse (HEK293, His) Q60819-1 (G33-K205) & P48346 (G30-S162) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78719 IL-15 Protein, Mouse (HEK293, Fc) P48346 (N49-S162) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78859 IL-15 Protein, Mouse (Biotinylated, HEK293, Fc-Avi) P48346 (N49-S162) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700193AF Animal-Free IL-15 Protein, Mouse (His) P48346 (N49-S162) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100754 Ritlecitinib Inhibitor 99.80% Yes
HY-132580 Tofersen Inhibitor 96.53% Unkown
HY-100754C Ritlecitinib tosylate Inhibitor 99.65% Yes
HY-100754A Ritlecitinib malonate Inhibitor / Unkown

Clinical Phase

Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P99410 Ordesekimab Inhibitor 99.08% Phase 2
HY-P99906 Sirexatamab 99.84% Phase 2
HY-P990719 Efbalropendekin alfa 97.17% Phase 1

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-132580A Tofersen sodium Inhibitor 97.55% Unkown
HY-15898 Y-320 99.03% Unkown
HY-102049 IL-15-IN-1 Inhibitor 99.79% Unkown
HY-Y0493 HODHBt Inhibitor 99.93% Unkown
HY-153050 JAK-IN-24 Inhibitor 99.35% Unkown
HY-RS06690 IL15 Human Pre-designed siRNA Set A / Unkown
HY-RS06691 Il15 Mouse Pre-designed siRNA Set A / Unkown
HY-RS06692 Il15 Rat Pre-designed siRNA Set A / Unkown
HY-RS06693 IL15RA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-132580S Tofersen-d27 Inhibitor / Unkown
HY-174635 Human IL15RA mRNA / Unkown
HY-174636 Human IL15 mRNA / Unkown
HY-RS19780 Il15ra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26277 Il15ra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990223 Anti-Mouse IL-15 Antibody (AIO.3) Inhibitor 95.00% Unkown
HY-P99759 Nogapendekin alfa (his tag) Agonist 98.62% Unkown
HY-P990446 Anti-IL-15 Antibody (DISC0280) Inhibitor 99.35% Unkown
HY-P992030 FB102 99.17% Unkown
HY-P990808 Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) Inhibitor 95% Unkown
HY-P991005 Larnefpendekin alfa Inhibitor 97.16% Unkown
HY-P992375 HuMax-IL15 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il15 NCBI NCBI:3600