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Tofersen (Synonyms: BIIB067; ISIS-SOD1Rx)

Cat. No.: HY-132580
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Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS).

For research use only. We do not sell to patients.

Tofersen Chemical Structure

Tofersen Chemical Structure

CAS No. : 2088232-70-4

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Description

Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS)[1].

In Vitro

Tofersen targets the SOD1 mRNA using antisense oligonucleotides (ASOs) that bind to the SOD1 mRNA by Watson-Crick base pairing. Tofersen activates RNase H1 that destroys the targeted RNA[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Tofersen
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HY-132580
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