JAK-IN-24 

JAK-IN-24 is a JAK inhibitor, with IC₅₀s of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP, respectively. JAK-IN-24 also inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC₅₀ of 86.171 nM^[1]. JAK-IN-24 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

JAK-IN-24 (Example 129 ) inhibits JAK with IC₅₀ values of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP respectively^[1].
JAK-IN-24 shows stability in human whole blood with t_1/2 of 267.223 min^[1].
JAK-IN-24 inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC₅₀ of 86.171 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

367.44

C₂₀H₂₅N₅O₂

2042629-43-4

Solid

White to off-white

C#CCOCCC1=CNC2=NC=NC(N[C@H]3CN([C@H](CC3)C)C(C=C)=O)=C21

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Atli Thorarensen, et al. Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof. Patent. WO2016178110.