IL-27R alpha/TCCR Protein, Human (HEK293, His)

IL-27R α/TCCR protein, as a receptor for IL27, relies on IL6ST/GP130 for signal transduction and activates STAT3 and STAT1. It is also part of the IL6ST/GP130 and CNTFR complex, acting as a receptor for the neuroprotective peptide human peptide. IL-27R alpha/TCCR Protein, Human (HEK293, His) is the recombinant human-derived IL-27R alpha/TCCR protein, expressed by HEK293 , with C-His labeled tag.

IL-27R alpha/TCCR, a receptor for IL27, relies on IL6ST/GP130 to facilitate signal transduction in response to IL27, operating through STAT3 and STAT1 pathways. This receptor is also implicated in the recognition of the neuroprotective peptide humanin, forming a complex with IL6ST/GP130 and CNTFR. Beyond its involvement in the regulation of Th1-type immune responses, IL-27R alpha/TCCR is associated with innate defense mechanisms. It forms part of a receptor complex comprising IL6ST/GP130, IL27RA/WSX1, and CNTFR, and this complex interacts with the neuroprotective peptide humanin.

Human

HEK293

C-His

Q6UWB1 (G34-K516)

9466  [NCBI]

Extracellular Domain

GSAGPLQCYGVGPLGDLNCSWEPLGDLGAPSELHLQSQKYRSNKTQTVAVAAGRSWVAIPREQLTMSDKLLVWGTKAGQPLWPPVFVNLETQMKPNAPRLGPDVDFSEDDPLEATVHWAPPTWPSHKVLICQFHYRRCQEAAWTLLEPELKTIPLTPVEIQDLELATGYKVYGRCRMEKEEDLWGEWSPILSFQTPPSAPKDVWVSGNLCGTPGGEEPLLLWKAPGPCVQVSYKVWFWVGGRELSPEGITCCCSLIPSGAEWARVSAVNATSWEPLTNLSLVCLDSASAPRSVAVSSIAGSTELLVTWQPGPGEPLEHVVDWARDGDPLEKLNWVRLPPGNLSALLPGNFTVGVPYRITVTAVSASGLASASSVWGFREELAPLVGPTLWRLQDAPPGTPAIAWGEVPRHQLRGHLTHYTLCAQSGTSPSVCMNVSGNTQSVTLPDLPWGPCELWVTASTIAGQGPPGPILRLHLPDNTLRWK

Approximately 75-105 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.