ST2/IL1RL1 Protein, Mouse (HEK293, Fc)

The ST2/IL1RL1 protein serves as a receptor for IL-33 and plays a crucial role in immunity and response to environmental stress through IL1RAP.It recruits MYD88, IRAK1/4 and TRAF6 upon stimulation, leading to MAPK phosphorylation.ST2/IL1RL1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived ST2/IL1RL1 protein, expressed by HEK293 , with C-hFc labeled tag.

ST2/IL1RL1 serves as a receptor for interleukin-33 (IL-33), playing crucial roles in innate and adaptive immunity to maintain tissue homeostasis and respond to environmental stresses, in conjunction with its coreceptor IL1RAP. Upon stimulation, it recruits MYD88, IRAK1, IRAK4, and TRAF6, leading to the phosphorylation of various MAPKs, including MAPK3/ERK1, MAPK1/ERK2, MAPK14, and MAPK8. This receptor is implicated in helper T-cell function and, in the context of tissue injury, induces a UCP2-dependent mitochondrial rewiring. This rewiring attenuates the generation of reactive oxygen species, preserving the integrity of the Krebs cycle. This preservation is essential for sustained production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. Additionally, ST2/IL1RL1 plays a role in inhibiting IL-33 signaling.

Immobilized canine IL33 at 2 μg/mL (100 μL/well) can bind mouse IL1RL1-Fc, the EC₅₀ of mouse IL1RL1-Fc is 64.2 μg/mL.

Mouse

HEK293

C-hFc

P14719-1/NP_001020773.1 (S27-R332)

17082  [NCBI]

Partial

SKSSWGLENEALIVRCPQRGRSTYPVEWYYSDTNESIPTQKRNRIFVSRDRLKFLPARVEDSGIYACVIRSPNLNKTGYLNVTIHKKPPSCNIPDYLMYSTVRGSDKNFKITCPTIDLYNWTAPVQWFKNCKALQEPRFRAHRSYLFIDNVTHDDEGDYTCQFTHAENGTNYIVTATRSFTVEEKGFSMFPVITNPPYNHTMEVEIGKPASIACSACFGKGSHFLADVLWQINKTVVGNFGEARIQEEEGRNESSSNDMDCLTSVLRITGVTEKDLSLEYDCLALNLHGMIRHTIRLRRKQPIDHR

Approximately 93.2 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 90%, as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.