Il1rl1 - interleukin 1 receptor-like 1 Gene

Also Known as T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17082

Summary

Enables interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including negative regulation of T-helper 1 type immune response; positive regulation of macrophage activation; and regulation of cytokine production. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in external side of plasma membrane and extracellular matrix. Is expressed in several structures, including immune system; musculoskeletal system; salivary gland; skin; and visual system. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1). [provided by Alliance of Genome Resources, Apr 2022]

Il1rl1 Products (3)

mRNA Protein Name
NM_001025602.3 NP_001020773.1 interleukin-1 receptor-like 1 isoform a precursor
NM_001294171.1 NP_001281100.1 interleukin-1 receptor-like 1 isoform b precursor
NM_010743.3 NP_034873.2 interleukin-1 receptor-like 1 isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables interleukin-33 binding IPI
IPI: Inferred from physical interaction
29045903 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17675517 MGI
Biological Process GO Annotation Evidence References Source
involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
34644537 MGI
involved in macrophage differentiation IMP
IMP: Inferred from mutant phenotype
34644537 MGI
involved in negative regulation of T-helper 1 type immune response IGI
IGI: Inferred from genetic interaction
18268038 MGI
involved in negative regulation of type II interferon production IGI
IGI: Inferred from genetic interaction
18268038 MGI
involved in positive regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
19841166 MGI
involved in positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
19841166 MGI
involved in positive regulation of interleukin-5 production IGI
IGI: Inferred from genetic interaction
18268038 MGI
involved in positive regulation of macrophage activation IMP
IMP: Inferred from mutant phenotype
19841166 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
12714518 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-1 receptor-like 1

  • interleukin-33 receptor alpha chain

  • lymphocyte antigen 84

Recombinant Il1rl1 Proteins

Cat. No. Product Name Accession Purity
HY-P72459 ST2/IL1RL1 Protein, Mouse (HEK293, His) P14719-2 (S27-A337) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76661 ST2/IL1RL1 Protein, Mouse (HEK293, Fc) P14719-1/NP_001020773.1 (S27-R332) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P76662 ST2/IL1RL1 Protein, Mouse (306a.a, HEK293, His) P14719-1/NP_001020773.1 (S27-R332) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06725 IL1RL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174607 Human IL33 mRNA / Unkown
HY-RS17312 Il1rl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23767 Il1rl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il1rl1 NCBI NCBI:9173