Ribulose 1,5-bisphosphate  (Synonyms: RuBP)

Ribulose 1,5-bisphosphate (RUBP) is a vital photosynthetic intermediate and substrate. Ribulose 1,5-bisphosphate acts as both product and substrate for Thermococcus kodakarensis KOD1 R15Pi. Ribulose 1,5-bisphosphate tightly binds to inactive RuBP carboxylase sites in plant leaves.Ribulose 1,5-bisphosphate serves as the key substrate for CO₂ fixation in photosynthesis. Ribulose 1,5-bisphosphate supports carboxylation and regeneration processes in photosynthesis. Ribulose 1,5-bisphosphate determines the dynamic transition temperature of photosynthetic control. Ribulose 1,5-bisphosphate can be used for photosynthesis and enzyme mechanism research^[1][2][3].

Ribulose 1,5-bisphosphate (RuBP) binds to inactive RuBP carboxylase sites in intact spinach leaves with an in vivo dissociation rate constant of 1.54 × 10^-3 s^-1[2].
Ribulose 1,5-bisphosphate binds to inactive RuBP carboxylase sites in intact sunflower leaves and declines to match inactive site levels within 60 s of darkening^[2].
Ribulose 1,5-bisphosphate supports carboxylation and regeneration that decline seasonally in Shiraz grapevines, with a dynamically shifting transition temperature^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

310.09

C₅H₁₂O₁₁P₂

24218-00-6

O=P(O)(O)OC[C@@H](O)[C@@H](O)C(COP(O)(O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Nakamura A, et al. Dynamic, ligand-dependent conformational change triggers reaction of ribose-1,5-bisphosphate isomerase from Thermococcus kodakarensis KOD1. J Biol Chem. 2012;287(25):20784-20796.  [Content Brief]

  [2]. Cardon ZG, et al. Evidence that Ribulose 1,5-Bisphosphate (RuBP) Binds to Inactive Sites of RuBP Carboxylase in Vivo and an Estimate of the Rate Constant for Dissociation. Plant Physiol. 1989 Apr;89(4):1253-7.  [Content Brief]

  [3]. Greer DH, et al. Modelling the seasonal changes in the gas exchange response to CO₂ in relation to short-term leaf temperature changes in Vitis vinifera cv. Shiraz grapevines grown in outdoor conditions. Plant Physiol Biochem. 2019;142:372-383.  [Content Brief]