Ro 04-5595 hydrochloride

Cat. No.: HY-107696: Fiche technique Instruction de manipulation
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Ro 04-5595 hydrochloride is a GluN2B-selective NMDA receptor antagonist (K_i: 31 nM).

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Ro 04-5595 hydrochloride Chemical Structure

CAS No. : 64047-73-0

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Other Forms of Ro 04-5595 hydrochloride:

Ro 04-5595 Obtenir un devis

Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform iGluR:

Voir toutes les isoformes

AMPA Receptor NMDA Receptor Kainate Receptor

Activité biologique
Pureté et documentation
Références
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Description

Ro 04-5595 hydrochloride is a GluN2B-selective NMDA receptor antagonist (K_i: 31 nM)^[1].

IC₅₀ & Target^[1]

GluN2B

31 nM (Ki)

In Vivo

Ro 04-5595 hydrochloride (5-20 mg/kg, i.p.) inhibits MA-induced locomotor stimulation in mice^[2].
Ro 04-5595 hydrochloride (10 mg/kg, i.p., for 6 days) reduced AMPA to NMDA ratio in Cocaine self-administering rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Methamphetamine (MA) treated mice^[1]
Dosage:	3-30 mg/kg
Administration:	i.p., given 30 min before injection of MA (2 mg/kg, i.p.)
Result:	Dose-dependently decreased MA-induced locomotor activity.

Masse moléculaire

368.30

Formule

C₁₉H₂₃Cl₂NO₂

CAS No.

64047-73-0

SMILES

ClC(C=C1)=CC=C1CCC2C3=CC(O)=C(OC)C=C3CCN2C.Cl

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Mutel V, et al. In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits. J Neurochem. 1998 May;70(5):2147-55. [Content Brief]

[2]. Li MH, et al. Amphetamine and Methamphetamine Increase NMDAR-GluN2B Synaptic Currents in Midbrain Dopamine Neurons. Neuropsychopharmacology. 2017 Jun;42(7):1539-1547. [Content Brief]

[3]. deBacker J, et al. GluN2B-containing NMDA receptors blockade rescues bidirectional synaptic plasticity in the bed nucleus of the stria terminalis of cocaine self-administering rats. Neuropsychopharmacology. 2015 Jan;40(2):394-405. [Content Brief]