Rp-cAMPS sodium salt

Name: Rp-cAMPS sodium salt
Brand: MedChemExpress
SKU: HY-100530D
Rating: 5.0 (5 reviews)

Cat. No.: HY-100530D Purity: 99.69%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (K_is of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases.

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Rp-cAMPS sodium salt 화학구조

CAS No. : 142439-94-9

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 5 publication(s) in Google Scholar

Other Forms of Rp-cAMPS sodium salt:

5 Publications Citing Use of MCE Rp-cAMPS sodium salt

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PKA PKAR PKACα

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)^[1]

In Vitro

A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

367.25

화학식

C₁₀H₁₁N₅NaO₅PS

CAS No.

142439-94-9

Appearance

Solid

Color

White to pink

SMILES

O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])O[P@@](OC2)([S-])=O)N3C4=C(C(N)=NC=N4)N=C3.[Na+]

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도

In Vitro:

H₂O : 100 mg/mL (272.29 mM; Need ultrasonic)

DMSO : 25 mg/mL (68.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7229 mL	13.6147 mL	27.2294 mL
5 mM	0.5446 mL	2.7229 mL	5.4459 mL
10 mM	0.2723 mL	1.3615 mL	2.7229 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (272.29 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.69%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (249 KB) HNMR (196 KB) CNMR (512 KB) LCMS (117 KB)

Handling Instructions (2659 KB)

References

[1]. R J de Wit, et al. Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases. Eur J Biochem. 1984 Jul 16;142(2):255-60. [Content Brief]

[2]. Rothermel JD, et al. A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem J. 1988 May 1;251(3):757-62. [Content Brief]

[3]. Fu Y, et al. PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. Mol Pain. 2008 Jul 16;4:26. [Content Brief]

[4]. Kuriyama S, et al. Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways. Invest Ophthalmol Vis Sci. 1995 Mar;36(3):730-6. [Content Brief]

[5]. Dostmann WR, et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91. [Content Brief]

[6]. Van Haastert PJ, et al. Competitive cAMP antagonists for cAMP-receptor proteins. J Biol Chem. 1984 Aug 25;259(16):10020-4. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.7229 mL	13.6147 mL	27.2294 mL	68.0735 mL
	5 mM	0.5446 mL	2.7229 mL	5.4459 mL	13.6147 mL
	10 mM	0.2723 mL	1.3615 mL	2.7229 mL	6.8074 mL
	15 mM	0.1815 mL	0.9076 mL	1.8153 mL	4.5382 mL
	20 mM	0.1361 mL	0.6807 mL	1.3615 mL	3.4037 mL
	25 mM	0.1089 mL	0.5446 mL	1.0892 mL	2.7229 mL
	30 mM	0.0908 mL	0.4538 mL	0.9076 mL	2.2691 mL
	40 mM	0.0681 mL	0.3404 mL	0.6807 mL	1.7018 mL
	50 mM	0.0545 mL	0.2723 mL	0.5446 mL	1.3615 mL
	60 mM	0.0454 mL	0.2269 mL	0.4538 mL	1.1346 mL
H₂O	80 mM	0.0340 mL	0.1702 mL	0.3404 mL	0.8509 mL
H₂O	100 mM	0.0272 mL	0.1361 mL	0.2723 mL	0.6807 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.