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    Stem Cell/Wnt
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  3. Rp-cAMPS triethylammonium salt

Rp-cAMPS triethylammonium salt 

Cat. No.: HY-100530 Purity: >99.0%
Handling Instructions

Rp-cAMPS triethylammonium salt is an analog of cAMP which acts as a potent, competitive and cell-permeable antagonist of cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 6.05 µM and 9.75 µM, respectively). Rp-cAMPS triethylammonium salt is resistant to hydrolysis by phosphodiesterases.

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Rp-cAMPS triethylammonium salt Chemical Structure

Rp-cAMPS triethylammonium salt Chemical Structure

CAS No. : 151837-09-1

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Rp-cAMPS triethylammonium salt is an analog of cAMP which acts as a potent, competitive and cell-permeable antagonist of cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 6.05 µM and 9.75 µM, respectively). Rp-cAMPS triethylammonium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5].

IC50 & Target

Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)[1]

In Vitro

A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission[1].

In Vivo

Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons[1].

Molecular Weight

446.46

Formula

C₁₆H₂₇N₆O₅PS

CAS No.

151837-09-1

SMILES

O[[email protected]]1[[email protected]@H](O[[email protected]@]2([H])[[email protected]@]1([H])O[[email protected]@](OC2)(S)=O)N3C4=C(C(N)=NC=N4)N=C3.CCN(CC)CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

Rp-cAMPSPKAProtein kinase AcAMPmembrane-permeablesynapticneuronsPKA-IPKA-IIphosphodiesterasesresistantInhibitorinhibitorinhibit

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Rp-cAMPS triethylammonium salt
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HY-100530
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