1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
  2. PKA
  3. Rp-cAMPS sodium salt

Rp-cAMPS sodium salt 

Cat. No.: HY-100530D Purity: 99.98%
Handling Instructions

Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases.

For research use only. We do not sell to patients.

Rp-cAMPS sodium salt Chemical Structure

Rp-cAMPS sodium salt Chemical Structure

CAS No. : 142439-94-9

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1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Rp-cAMPS sodium salt:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Rp-cAMPS sodium salt

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Description

Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6].

IC50 & Target

Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)[1]

In Vitro

A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

367.25

Formula

C10H11N5NaO5PS

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (680.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7229 mL 13.6147 mL 27.2294 mL
5 mM 0.5446 mL 2.7229 mL 5.4459 mL
10 mM 0.2723 mL 1.3615 mL 2.7229 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Rp-cAMPS sodium salt
Cat. No.:
HY-100530D
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