PKA-IN-1
Based on 1 publication(s) in Google Scholar
PKA-IN-1 is a potent and selective cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor with an IC50 of 0.03 μM. PKA-IN-1 inhibits cAK in a fashion that is competitive with respect to ATP as substrate.
For research use only. We do not sell to patients.
- Purity: 99.82%
- CAS No.: 179985-52-5
- Formula: C13H11N3O
- Molecular Weight:225.25
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) PKA-IN-1
More
Biological Activity
IC50: 0.03 μM (cAK)[1]
PKA-IN-1 (compounds A1) is ineffective or very poor inhibitors of wheat embryo Ca2+-dependent protein kinase (CDPK) and rat brain Ca2+-dependent protein kinase C (PKC), chicken gizzard myosin light chain kinase (MLCK) and potato tuber cyclic nucleotide-binding phosphatase (Pase).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 179985-52-5
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Appearance Solid
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Molecular Weight 225.25
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Formula C13H11N3O
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Color Off-white to pink
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SMILES
CC(NC1=NC(C)=C(C#N)C2=C1C=CC=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Vet Microbiol
Phosphorylation of T425 and methylation of R426 synergistically regulate IBDV VP1 function and viral replication. [Abstract]2026 Feb:313:110871. PMID: 41506171
Solvent & Solubility
DMSO : 62.5 mg/mL (277.47 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4395 mL | 22.1976 mL | 44.3951 mL | 110.9878 mL |
| 5 mM | 0.8879 mL | 4.4395 mL | 8.8790 mL | 22.1976 mL | |
| 10 mM | 0.4440 mL | 2.2198 mL | 4.4395 mL | 11.0988 mL | |
| 15 mM | 0.2960 mL | 1.4798 mL | 2.9597 mL | 7.3992 mL | |
| 20 mM | 0.2220 mL | 1.1099 mL | 2.2198 mL | 5.5494 mL | |
| 25 mM | 0.1776 mL | 0.8879 mL | 1.7758 mL | 4.4395 mL | |
| 30 mM | 0.1480 mL | 0.7399 mL | 1.4798 mL | 3.6996 mL | |
| 40 mM | 0.1110 mL | 0.5549 mL | 1.1099 mL | 2.7747 mL | |
| 50 mM | 0.0888 mL | 0.4440 mL | 0.8879 mL | 2.2198 mL | |
| 60 mM | 0.0740 mL | 0.3700 mL | 0.7399 mL | 1.8498 mL | |
| 80 mM | 0.0555 mL | 0.2775 mL | 0.5549 mL | 1.3873 mL | |
| 100 mM | 0.0444 mL | 0.2220 mL | 0.4440 mL | 1.1099 mL |
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