1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
  2. PKA
  3. Metadoxine


Cat. No.: HY-B1898 Purity: 99.92%
Handling Instructions

Metadoxine blocks adipocyte differentiation in association with inhibition of the protein kinase A-cAMP response element binding protein (PKA-CREB) pathway.

For research use only. We do not sell to patients.

Metadoxine Chemical Structure

Metadoxine Chemical Structure

CAS No. : 74536-44-0

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1  mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Metadoxine blocks adipocyte differentiation in association with inhibition of the protein kinase A-cAMP response element binding protein (PKA-CREB) pathway.

In Vitro

Simultaneous Metadoxine treatment notably inhibits adipogenic differentiation in a dose-dependent manner. Metadoxine treatment from day 4 through day 8 is required for inhibition of MDI-induced preadipocyte differentiation[1]. Metadoxine prevents glutathione depletion and the increase in lipid peroxidation damage caused by ethanol and acetaldehyde in HepG2 cells. In hepatic stellate cells, Metadoxine prevents the increase in collagen and attenuated TNF-α secretion caused by acetaldehyde. Thus, Metadoxine could be useful in preventing the damage produced in early stages of alcoholic liver disease as it prevents the redox imbalance of the hepatocytes and prevents TNF-α induction, one of the earliest events in hepatic damage[2].

Clinical Trial
Molecular Weight







O=C(O)[[email protected]](CC1)NC1=O.OCC2=C(CO)C(O)=C(C)N=C2


Room temperature in continental US; may vary elsewhere.


4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 155 mg/mL (519.63 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3524 mL 16.7622 mL 33.5244 mL
5 mM 0.6705 mL 3.3524 mL 6.7049 mL
10 mM 0.3352 mL 1.6762 mL 3.3524 mL
*Please refer to the solubility information to select the appropriate solvent.
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MetadoxinePKAProtein kinase AInhibitorinhibitorinhibit

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